HIAT2015 - List of Authors (Noda, K.)

Paper	Title	Page
MOPA02	Beam Alignment Procedure for Scanned Ion-Beam Therapy	36
	Y. Saraya, T. Furukawa, Y. Hara, K. Mizushima, K. Noda, N. S. Saotome, T. Shirai, R. Tansho NIRS, Chiba-shi, Japan E. Takeshita Kanagawa Cancer Center, Ion-beam Radiation Oncology Center in Kanagawa, Kanagawa, Japan
	It's important to control the beam position for the 3D pencil-beam scanning because the position accuracy of the beam has a serious matter on the alignment of the irradiation field. In order to suppress this matter, we have been developed a simple procedure for the beam tuning. The fluctuation of the beam position is tuned with the steering magnets (ST) and the fluorescent screen monitors (SCN). At first, the beam positions are measured by two SCN and the kick angles of two ST are calculated using deviates from the center of the beam position measured by SCN and the transfer matrix. After the tuning, the beam position at the isocenter is checked on the verification system for the alignment of the beam consists of the SCN and the iron sphere phantom. If the beam position is deviated from the center, one of ST placed on most downstream of the beam transport line will be corrected. These adjustments are iterated until the deviation for all energies of the beam are within 0.5 mm. We have been performed the beam commissioning using our procedure in Kanagawa Cancer Center. In this presentation, we will report on the result of these measurements.
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MOPA08	The Multi Particle Simulation for the Cyclotron NIRS-930	51
	M. Nakao, S. Hojo, K. Katagiri, A. Noda, K. Noda, A. Sugiura, T. Wakui NIRS, Chiba-shi, Japan A. Goto Yamagata University, Yamagata, Japan V.L. Smirnov, S.B. Vorozhtsov JINR, Dubna, Moscow Region, Russia
	The simulation of the beam for the cyclotron NIRS-930 at NIRS has been performed with the use of the SNOP program* in order to study beam dynamics in a cyclotron and to improve beam intensity. SNOP simulated from beam injection to extraction with the electric fields of the inflector, the Dee electrodes and the deflector; the magnetic fields of the main coils, the trim coils and the harmonic coils and the magnetic channel which were calculated by OPERA-3d. The simulation of proton with 30 MeV extraction energy with harmonic number of 1 was already performed and well simulated RF phase and extraction efficiency*. Then we tried to apply SNOP to 18 MeV protons with harmonic 2. We first formed isochronous magnetic field with main and trim coils for simulating single particle. Next we optimized electric deflector and magnetic channel in order to maximize extraction efficiency simulating the bunch of particles. Beam loss of the simulation was compared to the experiment. We intend to apply optimized simulation parameters for actual cyclotron operation to improve beam intensity and quality. V.L. Smirnov, S.B. Vorozhtsov, Proc. of RUPAC2012 TUPPB008 325 (2012) ** V.L. Smirnov et al., Proc. of IPAC2012 292 (2012)
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TUM2C03	Commissioning of Heavy-Ion Treatment Facility i-Rock in Kanagawa	130
	E. Takeshita, Y. Kusano, S. Minohara, S. Yamada Kanagawa Cancer Center, Ion-beam Radiation Oncology Center in Kanagawa, Kanagawa, Japan T. Furukawa, Y. Hara, K. Mizushima, K. Noda, N. S. Saotome, R. Tansho NIRS, Chiba-shi, Japan Y. Saraya National Institute of Radiological Sciences, Chiba, Japan
	As part of the Kanagawa "Challenge-10-year strategy to cancer" it was decided in March 2005 to establish a carbon-ion therapy system at the Kanagawa Cancer Center (KCC). From around 2009, the basic design and the foundational planning of the facility were considered and in January 2012 a contract was made with the Toshiba Corp. In December of the same year, construction of the main building for the acceleration and treatment devices has been started and completed in October 2014. Currently, the KCC is in a commissioning phase with the aim to start treatment in December this year. Various treatments for cancer, which include four present photon LINAC for the radiation therapy, will be provided to patients in cooperation with our cancer center hospital. In addition, we will combine a compact dissemination treatment system of carbon-ion therapy to the pencil beam 3D scanning technique designed by the National Institute of Radiological Sciences (NIRS). The treatment experience with the carbon-ion scanning technique is expected to be the second in the country following NIRS. In this presentation, we will report on the progress of the beam commissioning of the scanning system.
	Slides TUM2C03 [19.968 MB]
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WEPB03	Acceleration Scheme of Radioactive Ion Beam with HIMAC and its Injector Linac	197
	A. Noda, S. Hojo, K. Katagiri, M. Nakao, E. Noda, K. Noda, A. Sugiura, K. Suzuki, T. Wakui NIRS, Chiba-shi, Japan M. Grieser MPI-K, Heidelberg, Germany
	For the purpose of simultaneous real-time observation of irradiation effects in the patients body during a heavy ion cancer treatment, the capability of acceleration of radioactive ion beam such as 11C has been investigated where an ISOL based ion source combined with a cyclotron was assumed. According to recent development of a single charged 11C ion source and its charge breeder, it becomes to be important to estimate the intensities attainable by acceleration of such radioactive beam with the use of HIMAC and its injector quantitatively taking the beam dynamics into account. In the present paper, phase space matching of the secondary produced radioactive 11C ion beam is investigated among the ion source, injector linac and HIMAC synchrotron, referring to the ISOLDE system at CERN. : K. Katagiri et al., Contribution to this Sympojium.
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FRM1C01	Present Status of a Superconducting Rotating-Gantry for Carbon Therapy	288
	Y. Iwata, T. Furukawa, Y. Hara, S. Matsuba, S. Mori, K. Noda, S. Sato, T. Shirai, K. Shoda, R. Tansho NIRS, Chiba-shi, Japan N. Amemiya Kyoto University, Kyoto, Japan H. Arai, T. Fujimoto AEC, Chiba, Japan T.F. Fujita, K. Mizushima, Y. Saraya National Institute of Radiological Sciences, Chiba, Japan Y. Nagamoto, T. Orikasa, S. Takayama Toshiba, Yokohama, Japan T. Ogitsu KEK, Ibaraki, Japan
	A superconducting rotating-gantry for carbon therapy is being developed. This isocentric rotating gantry can transport carbon ions with the maximum energy of 430 MeV/u to an isocenter with irradiation angles of over 0-360 degrees, and is further capable of performing three-dimensional raster-scanning irradiation. The combined-function superconducting magnets were employed for the rotating gantry. The superconducting magnets with optimized beam optics allowed a compact gantry design with a large scan size at the isocenter; the length and the radius of the gantry are approximately 13 and 5.5 m, respectively, which are comparable to those for the existing proton gantries. Furthermore, the maximum scan size at the isocenter is calculated to be as large as approximately 200 mm square for heavy-ion beams at the maximum energy of 430 MeV/u. A construction and installation of the superconducting gantry is in progress, and beam commissioning will begin from this autumn. We will present a status of the superconducting rotating-gantry.
	Slides FRM1C01 [40.189 MB]
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FRM1C02	Research and Developments Toward Radioactive C-11 Ion Acceleration
	K. Katagiri, T. Hattori, S. Hojo, M. Muramatsu, M. Nakao, A. Noda, K. Noda, K. Suzuki, T. Wakui NIRS, Chiba-shi, Japan K. Nagatsu National Institute of Radiological Sciences, Inage, Chiba, Japan
	Funding: This study was partially supported by a JSPS KAKENHI Grant Number 25790090. An isotope Separation On-Line (ISOL) system for radioactive C-11 ion beam acceleration is expected to be realized for a PET imaging simultaneously with the heavy-ion cancer therapy. In the ISOL scheme, C-11 molecules are firstly produced by irradiating boron compound target with proton beams (20 MeV, ~30 μA) provided by a small cyclotron. The C-11 molecules are separated from impurity molecules mixed into the target chamber during the proton irradiation. Then, 1+ ions are firstly produced from the purified C-11 molecules with the singly charged ion source. Finally, after the isotope separation with an analyzing magnet, the C+ ions are further ionized by employing an EBIS as a charge breeder to obtain required charge state for the HIMAC injector.* We have been developed a C-11 molecular production/separation system to produce the C-11 molecules and separate it from the impurities. We have also been developed a new singly charged ion source to produce the 1+ ions. Moreover, a test irradiation port is being constructed at NIRS cyclotron facility for on-line experiments to produce C-11 ions. Latest results on those developments and prospects of our ISOL scheme are to be presented. *Akira Noda, et al., in these proceedings.
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Paper

Title

Page

Beam Alignment Procedure for Scanned Ion-Beam Therapy

36

Y. Saraya, T. Furukawa, Y. Hara, K. Mizushima, K. Noda, N. S. Saotome, T. Shirai, R. Tansho
NIRS, Chiba-shi, Japan
E. Takeshita
Kanagawa Cancer Center, Ion-beam Radiation Oncology Center in Kanagawa, Kanagawa, Japan

It's important to control the beam position for the 3D pencil-beam scanning because the position accuracy of the beam has a serious matter on the alignment of the irradiation field. In order to suppress this matter, we have been developed a simple procedure for the beam tuning. The fluctuation of the beam position is tuned with the steering magnets (ST) and the fluorescent screen monitors (SCN). At first, the beam positions are measured by two SCN and the kick angles of two ST are calculated using deviates from the center of the beam position measured by SCN and the transfer matrix. After the tuning, the beam position at the isocenter is checked on the verification system for the alignment of the beam consists of the SCN and the iron sphere phantom. If the beam position is deviated from the center, one of ST placed on most downstream of the beam transport line will be corrected. These adjustments are iterated until the deviation for all energies of the beam are within 0.5 mm. We have been performed the beam commissioning using our procedure in Kanagawa Cancer Center. In this presentation, we will report on the result of these measurements.

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MOPA08

The Multi Particle Simulation for the Cyclotron NIRS-930

51

M. Nakao, S. Hojo, K. Katagiri, A. Noda, K. Noda, A. Sugiura, T. Wakui
NIRS, Chiba-shi, Japan
A. Goto
Yamagata University, Yamagata, Japan
V.L. Smirnov, S.B. Vorozhtsov
JINR, Dubna, Moscow Region, Russia

The simulation of the beam for the cyclotron NIRS-930 at NIRS has been performed with the use of the SNOP program* in order to study beam dynamics in a cyclotron and to improve beam intensity. SNOP simulated from beam injection to extraction with the electric fields of the inflector, the Dee electrodes and the deflector; the magnetic fields of the main coils, the trim coils and the harmonic coils and the magnetic channel which were calculated by OPERA-3d. The simulation of proton with 30 MeV extraction energy with harmonic number of 1 was already performed and well simulated RF phase and extraction efficiency**. Then we tried to apply SNOP to 18 MeV protons with harmonic 2. We first formed isochronous magnetic field with main and trim coils for simulating single particle. Next we optimized electric deflector and magnetic channel in order to maximize extraction efficiency simulating the bunch of particles. Beam loss of the simulation was compared to the experiment. We intend to apply optimized simulation parameters for actual cyclotron operation to improve beam intensity and quality.
* V.L. Smirnov, S.B. Vorozhtsov, Proc. of RUPAC2012 TUPPB008 325 (2012)
** V.L. Smirnov et al., Proc. of IPAC2012 292 (2012)

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TUM2C03

Commissioning of Heavy-Ion Treatment Facility i-Rock in Kanagawa

130

E. Takeshita, Y. Kusano, S. Minohara, S. Yamada
Kanagawa Cancer Center, Ion-beam Radiation Oncology Center in Kanagawa, Kanagawa, Japan
T. Furukawa, Y. Hara, K. Mizushima, K. Noda, N. S. Saotome, R. Tansho
NIRS, Chiba-shi, Japan
Y. Saraya
National Institute of Radiological Sciences, Chiba, Japan

As part of the Kanagawa "Challenge-10-year strategy to cancer" it was decided in March 2005 to establish a carbon-ion therapy system at the Kanagawa Cancer Center (KCC). From around 2009, the basic design and the foundational planning of the facility were considered and in January 2012 a contract was made with the Toshiba Corp. In December of the same year, construction of the main building for the acceleration and treatment devices has been started and completed in October 2014. Currently, the KCC is in a commissioning phase with the aim to start treatment in December this year. Various treatments for cancer, which include four present photon LINAC for the radiation therapy, will be provided to patients in cooperation with our cancer center hospital. In addition, we will combine a compact dissemination treatment system of carbon-ion therapy to the pencil beam 3D scanning technique designed by the National Institute of Radiological Sciences (NIRS). The treatment experience with the carbon-ion scanning technique is expected to be the second in the country following NIRS. In this presentation, we will report on the progress of the beam commissioning of the scanning system.

Slides TUM2C03 [19.968 MB]

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WEPB03

Acceleration Scheme of Radioactive Ion Beam with HIMAC and its Injector Linac

197

A. Noda, S. Hojo, K. Katagiri, M. Nakao, E. Noda, K. Noda, A. Sugiura, K. Suzuki, T. Wakui
NIRS, Chiba-shi, Japan
M. Grieser
MPI-K, Heidelberg, Germany

For the purpose of simultaneous real-time observation of irradiation effects in the patients body during a heavy ion cancer treatment, the capability of acceleration of radioactive ion beam such as 11C has been investigated where an ISOL based ion source combined with a cyclotron was assumed. According to recent development of a single charged 11C ion source and its charge breeder*, it becomes to be important to estimate the intensities attainable by acceleration of such radioactive beam with the use of HIMAC and its injector quantitatively taking the beam dynamics into account. In the present paper, phase space matching of the secondary produced radioactive 11C ion beam is investigated among the ion source, injector linac and HIMAC synchrotron, referring to the ISOLDE system at CERN.
*: K. Katagiri et al., Contribution to this Sympojium.

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FRM1C01

Present Status of a Superconducting Rotating-Gantry for Carbon Therapy

288

Y. Iwata, T. Furukawa, Y. Hara, S. Matsuba, S. Mori, K. Noda, S. Sato, T. Shirai, K. Shoda, R. Tansho
NIRS, Chiba-shi, Japan
N. Amemiya
Kyoto University, Kyoto, Japan
H. Arai, T. Fujimoto
AEC, Chiba, Japan
T.F. Fujita, K. Mizushima, Y. Saraya
National Institute of Radiological Sciences, Chiba, Japan
Y. Nagamoto, T. Orikasa, S. Takayama
Toshiba, Yokohama, Japan
T. Ogitsu
KEK, Ibaraki, Japan

A superconducting rotating-gantry for carbon therapy is being developed. This isocentric rotating gantry can transport carbon ions with the maximum energy of 430 MeV/u to an isocenter with irradiation angles of over 0-360 degrees, and is further capable of performing three-dimensional raster-scanning irradiation. The combined-function superconducting magnets were employed for the rotating gantry. The superconducting magnets with optimized beam optics allowed a compact gantry design with a large scan size at the isocenter; the length and the radius of the gantry are approximately 13 and 5.5 m, respectively, which are comparable to those for the existing proton gantries. Furthermore, the maximum scan size at the isocenter is calculated to be as large as approximately 200 mm square for heavy-ion beams at the maximum energy of 430 MeV/u. A construction and installation of the superconducting gantry is in progress, and beam commissioning will begin from this autumn. We will present a status of the superconducting rotating-gantry.

Slides FRM1C01 [40.189 MB]

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FRM1C02

Research and Developments Toward Radioactive C-11 Ion Acceleration

K. Katagiri, T. Hattori, S. Hojo, M. Muramatsu, M. Nakao, A. Noda, K. Noda, K. Suzuki, T. Wakui
NIRS, Chiba-shi, Japan
K. Nagatsu
National Institute of Radiological Sciences, Inage, Chiba, Japan

Funding: This study was partially supported by a JSPS KAKENHI Grant Number 25790090.
An isotope Separation On-Line (ISOL) system for radioactive C-11 ion beam acceleration is expected to be realized for a PET imaging simultaneously with the heavy-ion cancer therapy. In the ISOL scheme, C-11 molecules are firstly produced by irradiating boron compound target with proton beams (20 MeV, ~30 μA) provided by a small cyclotron. The C-11 molecules are separated from impurity molecules mixed into the target chamber during the proton irradiation. Then, 1+ ions are firstly produced from the purified C-11 molecules with the singly charged ion source. Finally, after the isotope separation with an analyzing magnet, the C+ ions are further ionized by employing an EBIS as a charge breeder to obtain required charge state for the HIMAC injector.* We have been developed a C-11 molecular production/separation system to produce the C-11 molecules and separate it from the impurities. We have also been developed a new singly charged ion source to produce the 1+ ions. Moreover, a test irradiation port is being constructed at NIRS cyclotron facility for on-line experiments to produce C-11 ions. Latest results on those developments and prospects of our ISOL scheme are to be presented.
*Akira Noda, et al., in these proceedings.

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