Author: Heufelder, J.
Paper Title Page
MOPAB419 Acceleration and Measurement of Alpha Particles and Hydrogen Molecular Ions with the HZB Cyclotron 1264
 
  • G. Kourkafas, J. Bundesmann, A. Denker, T. Fanselow, J. Röhrich
    HZB, Berlin, Germany
  • J. Heufelder, A. Weber
    Charite, Berlin, Germany
  
  The HZB cy­clotron has treated more than 4000 pa­tients with eye tu­mors using pro­tons. The ac­cel­er­a­tor can also pro­vide heav­ier ions which could be suit­able for oc­u­lar ra­di­a­tion ther­apy. He­lium ions ex­hibit less lat­eral spread, in­creased rel­a­tive bi­o­log­i­cal ef­fec­tive­ness and a sharper Bragg-Peak com­pared to pro­tons of the same range, while min­i­miz­ing nu­clear frag­men­ta­tion and thus ex­ces­sive dose down­stream the ir­ra­di­ated vol­ume com­pared to more heavy ions. When ac­cel­er­at­ing fully stripped he­lium ions (alpha par­ti­cles), hy­dro­gen mol­e­c­u­lar ions can also be ac­cel­er­ated to the same en­ergy with a small tun­ing of the ma­chine due to hav­ing al­most the same mass-to-charge ratio, yield­ing a pro­ton beam of dou­ble cur­rent after the beam exits the vac­uum win­dow to­wards the tar­get. The ac­cel­er­a­tion and char­ac­ter­i­za­tion of these two ion species are de­scribed in this paper, sug­gest­ing the fea­si­bil­ity of a cor­re­spond­ing clin­i­cal cy­clotron for oc­u­lar or even deep-seated tu­mors.  
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DOI • reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2021-MOPAB419  
About • paper received ※ 19 May 2021       paper accepted ※ 09 June 2021       issue date ※ 13 August 2021  
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