IPAC2021 - List of Authors (Benedetto, E.)

Paper	Title	Page
MOPAB182	Automated Synchrotron Lattice Design and Optimisation Using a Multi-Objective Genetic Algorithm	616
	X. Zhang, S.L. Sheehy The University of Melbourne, Melbourne, Victoria, Australia E. Benedetto TERA, Novara, Italy E. Benedetto CERN, Meyrin, Switzerland
	Funding: This work is partially supported by the Australian Government Research Training Program Scholarship. As part of the Next Ion Medical Machine Study (NIMMS), we present a new method for designing synchrotron lattices. A step-wise approach was used to generate random lattice structures from a set of feedforward neural networks. These lattice designs are optimised by evolving the networks over many iterations with a multi-objective genetic algorithm (MOGA). The final set of solutions represent the most effi- cient and feasible lattices which satisfy the design constraints. It is up to the lattice designer to choose a design that best suits the intended application. The automated algorithm presented here randomly samples from all possible lattice layouts and reaches the global optimum over many iterations. The requirements of an efficient extraction scheme in hadron therapy synchrotrons impose stringent constraints on the lat- tice optical functions. Using this algorithm allows us to find the global optimum that is tailored to these constraints and to fully utilise the flexibilities provided by new technology.
	Poster MOPAB182 [6.006 MB]
DOI •	reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2021-MOPAB182
About •	paper received ※ 15 May 2021 paper accepted ※ 23 June 2021 issue date ※ 14 August 2021
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MOPAB413	The Next Ion Medical Machine Study at CERN: Towards a Next Generation Cancer Research and Therapy Facility with Ion Beams	1240
	M. Vretenar, V. Bencini, E. Benedetto, M.R. Khalvati, A.M. Lombardi, M. Sapinski, D. Tommasini CERN, Geneva, Switzerland E. Benedetto, M. Sapinski TERA, Novara, Italy P. Foka GSI, Darmstadt, Germany
	Cancer therapy with ions has several advantages over X-ray and proton therapy, but its diffusion remains limited primarily because of the size and cost of the accelerator. To develop technologies that might improve performance and reduce accelerator cost with respect to present facilities, CERN has recently launched the Next Ion Medical Machine Study (NIMMS), leveraging CERN expertise in accelerator fields to disseminate technologies developed for basic science. A perspective user and key partner of NIMMS is the SEEIIST (South East European International Institute for Sustainable Technologies), established to build in the region an innovative facility for combined cancer therapy and biomedical research with ion beams. For SEEIIST and other potential users, three options are being considered. Conceptual designs of a warm-magnet synchrotron at high beam intensity, of a compact superconducting synchrotron, and of a high-frequency linear accelerator have been compared in terms of cost, risk and development time. The development of curved superconducting magnets, of compact synchrotrons and ion gantries, and of linacs is being pursued within EU-funded projects or specific collaborations
DOI •	reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2021-MOPAB413
About •	paper received ※ 18 May 2021 paper accepted ※ 20 July 2021 issue date ※ 13 August 2021
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MOPAB414	A Novel Facility for Cancer Therapy and Biomedical Research with Heavy Ions for the South East European International Institute for Sustainable Technologies	1244
	S. Damjanovic, P. Grübling, H. Schopper SEEIIST, Geneva, Switzerland U. Amaldi, E. Benedetto, M. Sapinski TERA, Novara, Italy E. Benedetto, G. Bisoffi, M. Dosanjh, M. Sapinski, M. Vretenar CERN, Meyrin, Switzerland G. Bisoffi INFN/LNL, Legnaro (PD), Italy S. Damjanovic, M. Durante, P. Foka, C. Graeff GSI, Darmstadt, Germany Th. Haberer HIT, Heidelberg, Germany S. Rossi CNAO Foundation, Milan, Italy H.J. Specht Universität Heidelberg, Heidelberg, Germany
	The South East European International Institute for Sustainable Technologies (SEEIIST) proposes the construction of a major joint Research Infrastructure in the region, to rebuild cooperation after the recent wars and overcome lasting consequences like technology deficits and brain drain, having at its core a facility for cancer therapy and biomedical research with heavy ions. Beams of ions like Carbon are an advanced way to irradiate tumours but more research is needed, while the higher investment costs than for other radiation treatments have so far limited the European facilities to only four. This initiative aims at being strongly innovative, beyond the existing European designs. While the initial baseline relies on a conservative warm-magnet synchrotron, superconducting magnets for an advanced version of the synchrotron and for the gantry are being developed, with a potential for reductions in size, cost, and power consumption. Both warm and superconducting designs feature high beam intensity for faster treatment, and flexible extraction for novel treatment methods. A novel injector linac has the potential for producing radioisotopes in parallel with synchrotron injection.
DOI •	reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2021-MOPAB414
About •	paper received ※ 17 May 2021 paper accepted ※ 06 July 2021 issue date ※ 22 August 2021
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TUPAB402	Review of Technologies for Ion Therapy Accelerators	2465
	H.X.Q. Norman, R.B. Appleby, A.F. Steinberg UMAN, Manchester, United Kingdom E. Benedetto TERA, Novara, Italy E. Benedetto, M. Sapinski CERN, Meyrin, Switzerland H.L. Owen STFC/DL/ASTeC, Daresbury, Warrington, Cheshire, United Kingdom H.L. Owen Cockcroft Institute, Warrington, Cheshire, United Kingdom M. Sapinski GSI, Darmstadt, Germany S.L. Sheehy The University of Melbourne, Melbourne, Victoria, Australia
	Cancer therapy using protons and heavier ions such as carbon has demonstrated advantages over other radiotherapy treatments. To bring about the next generation of clinical facilities, the requirements are likely to reduce the footprint, obtain beam intensities above 1E10 particles per spill, and achieve faster extraction for more rapid, flexible treatment. This review follows the technical development of ion therapy, discussing how machine parameters have evolved, as well as trends emerging in technologies for novel treatments such as FLASH. To conclude, the future prospects of ion therapy accelerators are evaluated.
DOI •	reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2021-TUPAB402
About •	paper received ※ 19 May 2021 paper accepted ※ 28 July 2021 issue date ※ 24 August 2021
Export •	reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

Paper

Title

Page

Automated Synchrotron Lattice Design and Optimisation Using a Multi-Objective Genetic Algorithm

616

X. Zhang, S.L. Sheehy
The University of Melbourne, Melbourne, Victoria, Australia
E. Benedetto
TERA, Novara, Italy
E. Benedetto
CERN, Meyrin, Switzerland

Funding: This work is partially supported by the Australian Government Research Training Program Scholarship.
As part of the Next Ion Medical Machine Study (NIMMS), we present a new method for designing synchrotron lattices. A step-wise approach was used to generate random lattice structures from a set of feedforward neural networks. These lattice designs are optimised by evolving the networks over many iterations with a multi-objective genetic algorithm (MOGA). The final set of solutions represent the most effi- cient and feasible lattices which satisfy the design constraints. It is up to the lattice designer to choose a design that best suits the intended application. The automated algorithm presented here randomly samples from all possible lattice layouts and reaches the global optimum over many iterations. The requirements of an efficient extraction scheme in hadron therapy synchrotrons impose stringent constraints on the lat- tice optical functions. Using this algorithm allows us to find the global optimum that is tailored to these constraints and to fully utilise the flexibilities provided by new technology.

Poster MOPAB182 [6.006 MB]

DOI •

reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2021-MOPAB182

About •

paper received ※ 15 May 2021 paper accepted ※ 23 June 2021 issue date ※ 14 August 2021

Export •

reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

MOPAB413

The Next Ion Medical Machine Study at CERN: Towards a Next Generation Cancer Research and Therapy Facility with Ion Beams

1240

M. Vretenar, V. Bencini, E. Benedetto, M.R. Khalvati, A.M. Lombardi, M. Sapinski, D. Tommasini
CERN, Geneva, Switzerland
E. Benedetto, M. Sapinski
TERA, Novara, Italy
P. Foka
GSI, Darmstadt, Germany

Cancer therapy with ions has several advantages over X-ray and proton therapy, but its diffusion remains limited primarily because of the size and cost of the accelerator. To develop technologies that might improve performance and reduce accelerator cost with respect to present facilities, CERN has recently launched the Next Ion Medical Machine Study (NIMMS), leveraging CERN expertise in accelerator fields to disseminate technologies developed for basic science. A perspective user and key partner of NIMMS is the SEEIIST (South East European International Institute for Sustainable Technologies), established to build in the region an innovative facility for combined cancer therapy and biomedical research with ion beams. For SEEIIST and other potential users, three options are being considered. Conceptual designs of a warm-magnet synchrotron at high beam intensity, of a compact superconducting synchrotron, and of a high-frequency linear accelerator have been compared in terms of cost, risk and development time. The development of curved superconducting magnets, of compact synchrotrons and ion gantries, and of linacs is being pursued within EU-funded projects or specific collaborations

DOI •

reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2021-MOPAB413

About •

paper received ※ 18 May 2021 paper accepted ※ 20 July 2021 issue date ※ 13 August 2021

Export •

reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

MOPAB414

A Novel Facility for Cancer Therapy and Biomedical Research with Heavy Ions for the South East European International Institute for Sustainable Technologies

1244

S. Damjanovic, P. Grübling, H. Schopper
SEEIIST, Geneva, Switzerland
U. Amaldi, E. Benedetto, M. Sapinski
TERA, Novara, Italy
E. Benedetto, G. Bisoffi, M. Dosanjh, M. Sapinski, M. Vretenar
CERN, Meyrin, Switzerland
G. Bisoffi
INFN/LNL, Legnaro (PD), Italy
S. Damjanovic, M. Durante, P. Foka, C. Graeff
GSI, Darmstadt, Germany
Th. Haberer
HIT, Heidelberg, Germany
S. Rossi
CNAO Foundation, Milan, Italy
H.J. Specht
Universität Heidelberg, Heidelberg, Germany

The South East European International Institute for Sustainable Technologies (SEEIIST) proposes the construction of a major joint Research Infrastructure in the region, to rebuild cooperation after the recent wars and overcome lasting consequences like technology deficits and brain drain, having at its core a facility for cancer therapy and biomedical research with heavy ions. Beams of ions like Carbon are an advanced way to irradiate tumours but more research is needed, while the higher investment costs than for other radiation treatments have so far limited the European facilities to only four. This initiative aims at being strongly innovative, beyond the existing European designs. While the initial baseline relies on a conservative warm-magnet synchrotron, superconducting magnets for an advanced version of the synchrotron and for the gantry are being developed, with a potential for reductions in size, cost, and power consumption. Both warm and superconducting designs feature high beam intensity for faster treatment, and flexible extraction for novel treatment methods. A novel injector linac has the potential for producing radioisotopes in parallel with synchrotron injection.

DOI •

reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2021-MOPAB414

About •

paper received ※ 17 May 2021 paper accepted ※ 06 July 2021 issue date ※ 22 August 2021

Export •

reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

TUPAB402

Review of Technologies for Ion Therapy Accelerators

2465

H.X.Q. Norman, R.B. Appleby, A.F. Steinberg
UMAN, Manchester, United Kingdom
E. Benedetto
TERA, Novara, Italy
E. Benedetto, M. Sapinski
CERN, Meyrin, Switzerland
H.L. Owen
STFC/DL/ASTeC, Daresbury, Warrington, Cheshire, United Kingdom
H.L. Owen
Cockcroft Institute, Warrington, Cheshire, United Kingdom
M. Sapinski
GSI, Darmstadt, Germany
S.L. Sheehy
The University of Melbourne, Melbourne, Victoria, Australia

Cancer therapy using protons and heavier ions such as carbon has demonstrated advantages over other radiotherapy treatments. To bring about the next generation of clinical facilities, the requirements are likely to reduce the footprint, obtain beam intensities above 1E10 particles per spill, and achieve faster extraction for more rapid, flexible treatment. This review follows the technical development of ion therapy, discussing how machine parameters have evolved, as well as trends emerging in technologies for novel treatments such as FLASH. To conclude, the future prospects of ion therapy accelerators are evaluated.

DOI •

reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2021-TUPAB402

About •

paper received ※ 19 May 2021 paper accepted ※ 28 July 2021 issue date ※ 24 August 2021

Export •

reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)