Author: Benedetto, E.
Paper Title Page
MOPAB182 Automated Synchrotron Lattice Design and Optimisation Using a Multi-Objective Genetic Algorithm 616
 
  • X. Zhang, S.L. Sheehy
    The University of Melbourne, Melbourne, Victoria, Australia
  • E. Benedetto
    TERA, Novara, Italy
  • E. Benedetto
    CERN, Meyrin, Switzerland
  
  Funding: This work is partially supported by the Australian Government Research Training Program Scholarship.
As part of the Next Ion Med­ical Ma­chine Study (NIMMS), we pre­sent a new method for de­sign­ing syn­chro­tron lat­tices. A step-wise ap­proach was used to gen­er­ate ran­dom lat­tice struc­tures from a set of feed­for­ward neural net­works. These lat­tice de­signs are op­ti­mised by evolv­ing the net­works over many it­er­a­tions with a multi-ob­jec­tive ge­netic al­go­rithm (MOGA). The final set of so­lu­tions rep­re­sent the most effi- cient and fea­si­ble lat­tices which sat­isfy the de­sign con­straints. It is up to the lat­tice de­signer to choose a de­sign that best suits the in­tended ap­pli­ca­tion. The au­to­mated al­go­rithm pre­sented here ran­domly sam­ples from all pos­si­ble lat­tice lay­outs and reaches the global op­ti­mum over many it­er­a­tions. The re­quire­ments of an ef­fi­cient ex­trac­tion scheme in hadron ther­apy syn­chro­trons im­pose strin­gent con­straints on the lat- tice op­ti­cal func­tions. Using this al­go­rithm al­lows us to find the global op­ti­mum that is tai­lored to these con­straints and to fully utilise the flex­i­bil­i­ties pro­vided by new tech­nol­ogy. 		 
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DOI • reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2021-MOPAB182  
About • paper received ※ 15 May 2021       paper accepted ※ 23 June 2021       issue date ※ 14 August 2021  
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MOPAB413 The Next Ion Medical Machine Study at CERN: Towards a Next Generation Cancer Research and Therapy Facility with Ion Beams 1240
 
  • M. Vretenar, V. Bencini, E. Benedetto, M.R. Khalvati, A.M. Lombardi, M. Sapinski, D. Tommasini
    CERN, Geneva, Switzerland
  • E. Benedetto, M. Sapinski
    TERA, Novara, Italy
  • P. Foka
    GSI, Darmstadt, Germany
  
  Can­cer ther­apy with ions has sev­eral ad­van­tages over X-ray and pro­ton ther­apy, but its dif­fu­sion re­mains lim­ited pri­mar­ily be­cause of the size and cost of the ac­cel­er­a­tor. To de­velop tech­nolo­gies that might im­prove per­for­mance and re­duce ac­cel­er­a­tor cost with re­spect to pre­sent fa­cil­i­ties, CERN has re­cently launched the Next Ion Med­ical Ma­chine Study (NIMMS), lever­ag­ing CERN ex­per­tise in ac­cel­er­a­tor fields to dis­sem­i­nate tech­nolo­gies de­vel­oped for basic sci­ence. A per­spec­tive user and key part­ner of NIMMS is the SEEI­IST (South East Eu­ro­pean In­ter­na­tional In­sti­tute for Sus­tain­able Tech­nolo­gies), es­tab­lished to build in the re­gion an in­no­v­a­tive fa­cil­ity for com­bined can­cer ther­apy and bio­med­ical re­search with ion beams. For SEEI­IST and other po­ten­tial users, three op­tions are being con­sid­ered. Con­cep­tual de­signs of a warm-mag­net syn­chro­tron at high beam in­ten­sity, of a com­pact su­per­con­duct­ing syn­chro­tron, and of a high-fre­quency lin­ear ac­cel­er­a­tor have been com­pared in terms of cost, risk and de­vel­op­ment time. The de­vel­op­ment of curved su­per­con­duct­ing mag­nets, of com­pact syn­chro­trons and ion gantries, and of linacs is being pur­sued within EU-funded pro­jects or spe­cific col­lab­o­ra­tions  
DOI • reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2021-MOPAB413  
About • paper received ※ 18 May 2021       paper accepted ※ 20 July 2021       issue date ※ 13 August 2021  
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MOPAB414 A Novel Facility for Cancer Therapy and Biomedical Research with Heavy Ions for the South East European International Institute for Sustainable Technologies 1244
 
  • S. Damjanovic, P. Grübling, H. Schopper
    SEEIIST, Geneva, Switzerland
  • U. Amaldi, E. Benedetto, M. Sapinski
    TERA, Novara, Italy
  • E. Benedetto, G. Bisoffi, M. Dosanjh, M. Sapinski, M. Vretenar
    CERN, Meyrin, Switzerland
  • G. Bisoffi
    INFN/LNL, Legnaro (PD), Italy
  • S. Damjanovic, M. Durante, P. Foka, C. Graeff
    GSI, Darmstadt, Germany
  • Th. Haberer
    HIT, Heidelberg, Germany
  • S. Rossi
    CNAO Foundation, Milan, Italy
  • H.J. Specht
    Universität Heidelberg, Heidelberg, Germany
  
  The South East Eu­ro­pean In­ter­na­tional In­sti­tute for Sus­tain­able Tech­nolo­gies (SEEI­IST) pro­poses the con­struc­tion of a major joint Re­search In­fra­struc­ture in the re­gion, to re­build co­op­er­a­tion after the re­cent wars and over­come last­ing con­se­quences like tech­nol­ogy deficits and brain drain, hav­ing at its core a fa­cil­ity for can­cer ther­apy and bio­med­ical re­search with heavy ions. Beams of ions like Car­bon are an ad­vanced way to ir­ra­di­ate tu­mours but more re­search is needed, while the higher in­vest­ment costs than for other ra­di­a­tion treat­ments have so far lim­ited the Eu­ro­pean fa­cil­i­ties to only four. This ini­tia­tive aims at being strongly in­no­v­a­tive, be­yond the ex­ist­ing Eu­ro­pean de­signs. While the ini­tial base­line re­lies on a con­ser­v­a­tive warm-mag­net syn­chro­tron, su­per­con­duct­ing mag­nets for an ad­vanced ver­sion of the syn­chro­tron and for the gantry are being de­vel­oped, with a po­ten­tial for re­duc­tions in size, cost, and power con­sump­tion. Both warm and su­per­con­duct­ing de­signs fea­ture high beam in­ten­sity for faster treat­ment, and flex­i­ble ex­trac­tion for novel treat­ment meth­ods. A novel in­jec­tor linac has the po­ten­tial for pro­duc­ing ra­dioiso­topes in par­al­lel with syn­chro­tron in­jec­tion.  
DOI • reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2021-MOPAB414  
About • paper received ※ 17 May 2021       paper accepted ※ 06 July 2021       issue date ※ 22 August 2021  
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TUPAB402 Review of Technologies for Ion Therapy Accelerators 2465
 
  • H.X.Q. Norman, R.B. Appleby, A.F. Steinberg
    UMAN, Manchester, United Kingdom
  • E. Benedetto
    TERA, Novara, Italy
  • E. Benedetto, M. Sapinski
    CERN, Meyrin, Switzerland
  • H.L. Owen
    STFC/DL/ASTeC, Daresbury, Warrington, Cheshire, United Kingdom
  • H.L. Owen
    Cockcroft Institute, Warrington, Cheshire, United Kingdom
  • M. Sapinski
    GSI, Darmstadt, Germany
  • S.L. Sheehy
    The University of Melbourne, Melbourne, Victoria, Australia
  
  Can­cer ther­apy using pro­tons and heav­ier ions such as car­bon has demon­strated ad­van­tages over other ra­dio­ther­apy treat­ments. To bring about the next gen­er­a­tion of clin­i­cal fa­cil­i­ties, the re­quire­ments are likely to re­duce the foot­print, ob­tain beam in­ten­si­ties above 1E10 par­ti­cles per spill, and achieve faster ex­trac­tion for more rapid, flex­i­ble treat­ment. This re­view fol­lows the tech­ni­cal de­vel­op­ment of ion ther­apy, dis­cussing how ma­chine pa­ra­me­ters have evolved, as well as trends emerg­ing in tech­nolo­gies for novel treat­ments such as FLASH. To con­clude, the fu­ture prospects of ion ther­apy ac­cel­er­a­tors are eval­u­ated.  
DOI • reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2021-TUPAB402  
About • paper received ※ 19 May 2021       paper accepted ※ 28 July 2021       issue date ※ 24 August 2021  
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