Cyclotrons2016 - List of Authors (Kleeven, W.J.G.M.)

Paper	Title	Page
TUP03	Extraction System Design for the New IBA Cyclotron for PET Radioisotope Production	167
	W.J.G.M. Kleeven, E. Forton, E.K. Kral, B. Nactergal, V. Nuttens, S. Zaremba, J. van de Walle IBA, Louvain-la-Neuve, Belgium
	At IBA, we have designed, constructed, tested and industrialized an innovative isochronous cyclotron for PET isotope production. The design has been optimized for costeffectiveness, compactness, ease of maintenance and high performances, with a particular emphasis on its application and market. Multiple target stations can be placed around the vacuum chamber. An innovative extraction method (patent applications pending) has been designed which allows to obtain the same extracted beam sizes and properties on the target window independent of the target number. This is achieved by proper design and shaping of the magnet poles. This magnetic design is discussed together with beam dynamics simulations and beam extraction tests on the first machine.
	Poster TUP03 [1.246 MB]
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TUP04	Magnet Design of the New IBA Cyclotron for PET Radio-isotope Production	170
	S. Zaremba, S. De Neuter, W.J.G.M. Kleeven, B. Nactergal, V. Nuttens, J. van de Walle IBA, Louvain-la-Neuve, Belgium
	An innovative isochronous cyclotron for PET radioisotope production has been designed, constructed, tested and industrialized at Ion Beam Applications (IBA) [1]. This cyclotron (patent application pending) produces 18MeV proton beam and is called the Cyclone® KIUBE. The design has been optimized for cost-effectiveness, compactness, ease of maintenance and high performance, which are key elements considering its application in the dedicated market. Compared to the previous 18 MeV protons and 9 MeV deuteron machine from IBA, Cyclone® 18/9, the gap between the poles has been reduced from 30 to 24 mm and the method of shimming to obtain isochronous magnetic field has been reviewed thoroughly. In early 2016, the prototype Cyclone® KIUBE was successfully commissioned at the IBA factory and the observed proton beam intensity outperformed Cyclone® 18/9.
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TUP05	Installation and Commissioning of the First Cyclone®70p	173
	B. Nactergal, J.L. Delvaux, J.-M. Geets, W.J.G.M. Kleeven, T. Vanderlinden, R. Vigneron, S. Zaremba IBA, Louvain-la-Neuve, Belgium
	In October 2013, IBA sold its first Cyclone®70p, ex-tracted 70 MeV proton machine to Zevacor Pharma, Indianapolis, IN, USA. This brand new machine combine the advantages of the design of the Cyclone®30 HC (1,5mA extracted beam) and the Cyclone®70 XP (multi-particle). Moreover, this high energy cyclotron has been optimized for H⁻ ions acceleration, activation reduction and long term beam production. The installation will be used for high power and long term irradiations of rubidium Rb targets to produce stron-tium 82Sr generator applied in the field of cardiac imaging. From cyclotron to beam lines and up to the target sta-tion, all subsystems have been reviewed to reach highest level of quality, reduce the activation (by the use of low activation material and reduction of beam losses) and finally optimized the maintenance. For that delivery, the machine will be equipped with 6 beam transport lines and 2 solid target station units. In June 2015, about 21 months after contract signature, the IBA Factory Acceptance Tests have been successfully performed in Belgium and the machine was shipped to Indianapolis, IN, USA to be installed in Customer factory cyclotron vault.
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TUP06	Design of the Cyclone®70p	175
	S. Zaremba, M. Abs, J.L. Delvaux, W.J.G.M. Kleeven, B. Nactergal, V. Nuttens, J. van de Walle IBA, Louvain-la-Neuve, Belgium
	The IBA CYCLONE®70p is a high intensity 70 MeV proton-only cyclotron dedicated to the production of radioisotopes for PET generators and SPECT. The nominal power of the extracted beam goes above 50kW (750μA@70MeV). The proton-only cyclotron was developed based on the previous experience of the multi-particle Cyclone® 70XP running in Nantes, France. Numerical tools have been extensively used to optimize the magnetic field, to avoid potentially harmful resonances during acceleration and improve the acceleration efficiency of the cyclotron. In addition, electromagnetic and mechanical calculations permitted to obtain a low dissipated power and electromechanically robust design of the RF system. The vacuum computations have permitted to optimize the beam transmission, the placement and type of cryopumps. This new development of CYCLONE®70p was the initial part of the successfully finished IBA project also presented during this conference [1].
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TUP07	Commissioning and Testing of the First IBA S2C2	178
	S. Henrotin, M. Abs, E. Forton, Y. Jongen, W.J.G.M. Kleeven, P. Verbruggen, J. van de Walle IBA, Louvain-la-Neuve, Belgium
	The first unit of the IBA superconducting synchrocyclotron (S2C2) has been installed in Nice, France, and is currently being commissioned. In this communication, we will present some issues encountered during the commissioning of our first synchrocyclotron for protontherapy. We will mainly focus on beam aspects, showing the influence of several machine parameters on beam properties like stability, energy and intensity.
	Poster TUP07 [1.403 MB]
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TUD03	Development of the Cyclone® Kiube: A Compact, High Performance and Self-Shielded Cyclotron for Radioisotope Production	238
	B. Nactergal, M. Abs, S. De Neuter, W.J.G.M. Kleeven, E.K. Kral, V. Nuttens, S. Zaremba, J. van de Walle IBA, Louvain-la-Neuve, Belgium
	About 15 months ago, at IBA, we have launched the design, construction, tests and industrialization of an innovative isochronous cyclotron for PET isotope production (patent applications pending). The design has been optimized for cost effectiveness, compactness, ease of maintenance, activation reduction and high performances, with a particular emphasis on its application on market. Multiple target stations can be placed around the vacuum chamber. An innovative extraction method (patent applications pending) has been designed which allows to obtain the same extracted beam sizes and properties on the target window independent of the target position.
	Slides TUD03 [2.687 MB]
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WEA01	Some Examples of Recent Progress of Beam-Dynamics Studies for Cyclotrons	244
	W.J.G.M. Kleeven IBA, Louvain-la-Neuve, Belgium
	Two subjects are highlighted. The first is the problem of high space charge effects in cyclotrons. The second is the the progress in development of tools and simulations for industrial and medical cyclotrons at IBA.
	Slides WEA01 [2.060 MB]
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THB01	The S2C2: From Source to Extraction	285
	J. van de Walle, M. Abs, E. Forton, S. Henrotin, Y. Jongen, W.J.G.M. Kleeven, P. Verbruggen IBA, Louvain-la-Neuve, Belgium M. Conjat, J. Mandrillon, P. Mandrillon AIMA, Nice, France
	Apart from being the first constructed superconducting accelerator, the S2C2 is also the first synchro-cyclotron at IBA. To study the beam dynamics, new computational tools had to be developed dealing with much larger number of turns, the longitudinal capture in the central region and the regenerative extraction. The S2C2 is a medical accelerator requiring a precise control of the beam characteristics so a deep understanding of beam dynamics is mandatory. Our simulation strategy allows to gain important insight in the acceleration process and beam characteristics: the beam emittance and energy spread, beam losses, effects of coil misalignments, median plane errors, resonances, etc. The simulation tools are split in three parts. At first, protons are tracked from the source up to about 3 MeV with the in-house tracking code AOC. In a second part, only the energy, RF phase and orbit centers are tracked as a function of time. Finally, a detailed tracking from 225 MeV up to extraction is performed with AOC. Simulations are compared to experimental observations during in-factory testing and commissioning of the first S2C2 installed in Nice, France.
	Slides THB01 [2.574 MB]
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FRA02	The IBA S2C2: From First Unit to Industrial Product
	E. Forton, T. Colmant, S. Henrotin, W.J.G.M. Kleeven, S. Quets, P. Verbruggen, J. van de Walle IBA, Louvain-la-Neuve, Belgium
	While the first unit of the S2C2, IBA's synchrocyclotron dedicated to proton therapy, was being tested and validated for clinical operation, the "Research and Development" and "Manufacturing and Supply Chain" departments teamed up to industrialize the design, start the series production of the first batch and planned for a production ramp up. In this communication, we will describe how the team was gathered, how IBA interfaced with suppliers who also had to ramp up the production of critical components, what deliverables were required for the industrialization and how the engineers were trained for the testing and installation. We will also present how IBA will increase its manufacturing capability to cope with the already high demand from the market for this new accelerator.
	Slides FRA02 [6.712 MB]
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Paper

Title

Page

Extraction System Design for the New IBA Cyclotron for PET Radioisotope Production

167

W.J.G.M. Kleeven, E. Forton, E.K. Kral, B. Nactergal, V. Nuttens, S. Zaremba, J. van de Walle
IBA, Louvain-la-Neuve, Belgium

At IBA, we have designed, constructed, tested and industrialized an innovative isochronous cyclotron for PET isotope production. The design has been optimized for costeffectiveness, compactness, ease of maintenance and high performances, with a particular emphasis on its application and market. Multiple target stations can be placed around the vacuum chamber. An innovative extraction method (patent applications pending) has been designed which allows to obtain the same extracted beam sizes and properties on the target window independent of the target number. This is achieved by proper design and shaping of the magnet poles. This magnetic design is discussed together with beam dynamics simulations and beam extraction tests on the first machine.

Poster TUP03 [1.246 MB]

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reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

TUP04

Magnet Design of the New IBA Cyclotron for PET Radio-isotope Production

170

S. Zaremba, S. De Neuter, W.J.G.M. Kleeven, B. Nactergal, V. Nuttens, J. van de Walle
IBA, Louvain-la-Neuve, Belgium

An innovative isochronous cyclotron for PET radioisotope production has been designed, constructed, tested and industrialized at Ion Beam Applications (IBA) [1]. This cyclotron (patent application pending) produces 18MeV proton beam and is called the Cyclone® KIUBE. The design has been optimized for cost-effectiveness, compactness, ease of maintenance and high performance, which are key elements considering its application in the dedicated market. Compared to the previous 18 MeV protons and 9 MeV deuteron machine from IBA, Cyclone® 18/9, the gap between the poles has been reduced from 30 to 24 mm and the method of shimming to obtain isochronous magnetic field has been reviewed thoroughly. In early 2016, the prototype Cyclone® KIUBE was successfully commissioned at the IBA factory and the observed proton beam intensity outperformed Cyclone® 18/9.

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reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

TUP05

Installation and Commissioning of the First Cyclone®70p

173

B. Nactergal, J.L. Delvaux, J.-M. Geets, W.J.G.M. Kleeven, T. Vanderlinden, R. Vigneron, S. Zaremba
IBA, Louvain-la-Neuve, Belgium

In October 2013, IBA sold its first Cyclone®70p, ex-tracted 70 MeV proton machine to Zevacor Pharma, Indianapolis, IN, USA. This brand new machine combine the advantages of the design of the Cyclone®30 HC (1,5mA extracted beam) and the Cyclone®70 XP (multi-particle). Moreover, this high energy cyclotron has been optimized for H⁻ ions acceleration, activation reduction and long term beam production. The installation will be used for high power and long term irradiations of rubidium Rb targets to produce stron-tium 82Sr generator applied in the field of cardiac imaging. From cyclotron to beam lines and up to the target sta-tion, all subsystems have been reviewed to reach highest level of quality, reduce the activation (by the use of low activation material and reduction of beam losses) and finally optimized the maintenance. For that delivery, the machine will be equipped with 6 beam transport lines and 2 solid target station units. In June 2015, about 21 months after contract signature, the IBA Factory Acceptance Tests have been successfully performed in Belgium and the machine was shipped to Indianapolis, IN, USA to be installed in Customer factory cyclotron vault.

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TUP06

Design of the Cyclone®70p

175

S. Zaremba, M. Abs, J.L. Delvaux, W.J.G.M. Kleeven, B. Nactergal, V. Nuttens, J. van de Walle
IBA, Louvain-la-Neuve, Belgium

The IBA CYCLONE®70p is a high intensity 70 MeV proton-only cyclotron dedicated to the production of radioisotopes for PET generators and SPECT. The nominal power of the extracted beam goes above 50kW (750μA@70MeV). The proton-only cyclotron was developed based on the previous experience of the multi-particle Cyclone® 70XP running in Nantes, France. Numerical tools have been extensively used to optimize the magnetic field, to avoid potentially harmful resonances during acceleration and improve the acceleration efficiency of the cyclotron. In addition, electromagnetic and mechanical calculations permitted to obtain a low dissipated power and electromechanically robust design of the RF system. The vacuum computations have permitted to optimize the beam transmission, the placement and type of cryopumps. This new development of CYCLONE®70p was the initial part of the successfully finished IBA project also presented during this conference [1].

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TUP07

Commissioning and Testing of the First IBA S2C2

178

S. Henrotin, M. Abs, E. Forton, Y. Jongen, W.J.G.M. Kleeven, P. Verbruggen, J. van de Walle
IBA, Louvain-la-Neuve, Belgium

The first unit of the IBA superconducting synchrocyclotron (S2C2) has been installed in Nice, France, and is currently being commissioned. In this communication, we will present some issues encountered during the commissioning of our first synchrocyclotron for protontherapy. We will mainly focus on beam aspects, showing the influence of several machine parameters on beam properties like stability, energy and intensity.

Poster TUP07 [1.403 MB]

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TUD03

Development of the Cyclone® Kiube: A Compact, High Performance and Self-Shielded Cyclotron for Radioisotope Production

238

B. Nactergal, M. Abs, S. De Neuter, W.J.G.M. Kleeven, E.K. Kral, V. Nuttens, S. Zaremba, J. van de Walle
IBA, Louvain-la-Neuve, Belgium

About 15 months ago, at IBA, we have launched the design, construction, tests and industrialization of an innovative isochronous cyclotron for PET isotope production (patent applications pending). The design has been optimized for cost effectiveness, compactness, ease of maintenance, activation reduction and high performances, with a particular emphasis on its application on market. Multiple target stations can be placed around the vacuum chamber. An innovative extraction method (patent applications pending) has been designed which allows to obtain the same extracted beam sizes and properties on the target window independent of the target position.

Slides TUD03 [2.687 MB]

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WEA01

Some Examples of Recent Progress of Beam-Dynamics Studies for Cyclotrons

244

W.J.G.M. Kleeven
IBA, Louvain-la-Neuve, Belgium

Two subjects are highlighted. The first is the problem of high space charge effects in cyclotrons. The second is the the progress in development of tools and simulations for industrial and medical cyclotrons at IBA.

Slides WEA01 [2.060 MB]

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THB01

The S2C2: From Source to Extraction

285

J. van de Walle, M. Abs, E. Forton, S. Henrotin, Y. Jongen, W.J.G.M. Kleeven, P. Verbruggen
IBA, Louvain-la-Neuve, Belgium
M. Conjat, J. Mandrillon, P. Mandrillon
AIMA, Nice, France

Apart from being the first constructed superconducting accelerator, the S2C2 is also the first synchro-cyclotron at IBA. To study the beam dynamics, new computational tools had to be developed dealing with much larger number of turns, the longitudinal capture in the central region and the regenerative extraction. The S2C2 is a medical accelerator requiring a precise control of the beam characteristics so a deep understanding of beam dynamics is mandatory. Our simulation strategy allows to gain important insight in the acceleration process and beam characteristics: the beam emittance and energy spread, beam losses, effects of coil misalignments, median plane errors, resonances, etc. The simulation tools are split in three parts. At first, protons are tracked from the source up to about 3 MeV with the in-house tracking code AOC. In a second part, only the energy, RF phase and orbit centers are tracked as a function of time. Finally, a detailed tracking from 225 MeV up to extraction is performed with AOC. Simulations are compared to experimental observations during in-factory testing and commissioning of the first S2C2 installed in Nice, France.

Slides THB01 [2.574 MB]

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FRA02

The IBA S2C2: From First Unit to Industrial Product

E. Forton, T. Colmant, S. Henrotin, W.J.G.M. Kleeven, S. Quets, P. Verbruggen, J. van de Walle
IBA, Louvain-la-Neuve, Belgium

While the first unit of the S2C2, IBA's synchrocyclotron dedicated to proton therapy, was being tested and validated for clinical operation, the "Research and Development" and "Manufacturing and Supply Chain" departments teamed up to industrialize the design, start the series production of the first batch and planned for a production ramp up. In this communication, we will describe how the team was gathered, how IBA interfaced with suppliers who also had to ramp up the production of critical components, what deliverables were required for the industrialization and how the engineers were trained for the testing and installation. We will also present how IBA will increase its manufacturing capability to cope with the already high demand from the market for this new accelerator.

Slides FRA02 [6.712 MB]

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