IPAC2022 - List of Authors (Bisoffi, G.)

Paper	Title	Page
TUOZGD2	A Compact Synchrotron for Advanced Cancer Therapy with Helium and Proton Beams	811
THPOMS021	use link to see paper's listing under its alternate paper code
	M. Vretenar, M.E. Angoletta, J.C.C.M. Borburgh, L. Bottura, K. Paļskis, R.L. Taylor, G. Tranquille CERN, Meyrin, Switzerland E. Benedetto SEEIIST, Geneva, Switzerland G. Bisoffi INFN/LNL, Legnaro (PD), Italy M. Sapinski PSI, Villigen PSI, Switzerland
	Recent years have seen an increased interest in the use of helium for radiation therapy of cancer. Helium ions can be more precisely delivered to the tumour than protons or carbon ions, presently the only beams licensed for treatment, with a biological effectiveness between the two. The accelerator required for helium is considerably smaller than a standard carbon ion synchrotron. To exploit the potential of helium therapy and of other emerging particle therapy techniques, in the framework of the Next Ion Medical Machine Study (NIMMS) at CERN the design of a compact synchrotron optimised for acceleration of proton and helium beams has been investigated. The synchrotron is based on a new magnet design, profits from a novel injector linac, and can provide both slow and fast extraction for conventional and FLASH therapy. Production of mini-beams, and operation with multiple ions for imaging and treatment are also considered. This accelerator is intended to become the main element of a facility devoted to a programme of cancer research and treatment with proton and helium beams, to both cure patients and contribute to the assessment of helium beams as a new tool to fight cancer.
	Slides TUOZGD2 [1.940 MB]
DOI •	reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2022-TUOZGD2
About •	Received ※ 20 May 2022 — Revised ※ 11 June 2022 — Accepted ※ 16 June 2022 — Issue date ※ 11 July 2022
Cite •	reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

THPOMS022	Production of Radioisotopes for Cancer Imaging and Treatment with Compact Linear Accelerators	2996
	M. Vretenar, A. Mamaras CERN, Meyrin, Switzerland G. Bisoffi INFN/LNL, Legnaro (PD), Italy P. Foka GSI, Darmstadt, Germany
	Accelerator-produced radioisotopes are widely used in modern medicine, for imaging, for cancer therapy, and for combinations of therapy and diagnostics. Clinical trials are well advanced for several radioisotope-based treatments that might open the way to a strong request of specific accelerator systems dedicated to radioisotope production. While cyclotrons are the standard tool in this domain, we explore here alternative options using linear accelerators. Compared to cyclotrons, linacs have the advantage of modularity, compactness, and reduced beam loss with lower shielding requirements. Although in general more expensive than cyclotrons, linacs are competitive in cost for production of low-energy proton beams, or of intense beams of heavier particles. After a review of radioisotopes of potential interest, in particular those produced with low-energy protons or helium, this paper presents two linac-based isotope production systems. The first is a compact RFQ-based system for PET isotopes, and the second is an alpha-particle linac for production of alpha-emitters. The accelerator systems are described, together with calculations of production yields for different targets.
DOI •	reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2022-THPOMS022
About •	Received ※ 20 May 2022 — Revised ※ 15 June 2022 — Accepted ※ 16 June 2022 — Issue date ※ 17 June 2022
Cite •	reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

THPOMS049	Energy Comparison of Room Temperature and Superconducting Synchrotrons for Hadron Therapy	3080
	G. Bisoffi INFN/LNL, Legnaro (PD), Italy E. Benedetto, M. Karppinen, M.R. Khalvati, M. Vretenar, R. van Weelderen CERN, Meyrin, Switzerland M.G. Pullia, G. Venchi CNAO Foundation, Pavia, Italy L. Rossi INFN/LASA, Segrate (MI), Italy M. Sapinski PSI, Villigen PSI, Switzerland M. Sorbi Universita’ degli Studi di Milano & INFN, Segrate, Italy R.U. Valente La Sapienza University of Rome, Rome, Italy
	The yearly energy requirements of normal conducting (NC) and superconducting (SC) magnet options of a new hadron therapy (HT) facility are compared. Special reference is made to the layouts considered for the proposed SEEIIST facility. Benchmarking with the NC CNAO HT centre in Pavia (Italy) was carried out. The energy comparison is centred on the different synchrotron solutions, assuming the same injector and lines in the designs. The beam current is more than a factor 10 higher with respect to present generation facilities. This allows efficient ’multi-energy extraction’ (MEE), which shortens the therapy treatment and is needed especially in the SC option, because of the slow magnet ramping time. Hence, power values of the facility in the traditional mode were converted into MEE ones, for the sake of a fair stepwise comparison between NC and SC magnets. The use of cryocoolers and a liquefier are also compared, for synchrotron refrigeration. This study shows that a NC facility operated in MEE mode requires the least average energy, followed by the SC synchrotron solution with a liquefier, while the most energy intensive solution is the SC one with cryocoolers.
DOI •	reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2022-THPOMS049
About •	Received ※ 20 May 2022 — Revised ※ 17 June 2022 — Accepted ※ 28 June 2022 — Issue date ※ 10 July 2022
Cite •	reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

Paper

Title

Page

TUOZGD2

A Compact Synchrotron for Advanced Cancer Therapy with Helium and Proton Beams

811

THPOMS021

use link to see paper's listing under its alternate paper code

M. Vretenar, M.E. Angoletta, J.C.C.M. Borburgh, L. Bottura, K. Paļskis, R.L. Taylor, G. Tranquille
CERN, Meyrin, Switzerland
E. Benedetto
SEEIIST, Geneva, Switzerland
G. Bisoffi
INFN/LNL, Legnaro (PD), Italy
M. Sapinski
PSI, Villigen PSI, Switzerland

Recent years have seen an increased interest in the use of helium for radiation therapy of cancer. Helium ions can be more precisely delivered to the tumour than protons or carbon ions, presently the only beams licensed for treatment, with a biological effectiveness between the two. The accelerator required for helium is considerably smaller than a standard carbon ion synchrotron. To exploit the potential of helium therapy and of other emerging particle therapy techniques, in the framework of the Next Ion Medical Machine Study (NIMMS) at CERN the design of a compact synchrotron optimised for acceleration of proton and helium beams has been investigated. The synchrotron is based on a new magnet design, profits from a novel injector linac, and can provide both slow and fast extraction for conventional and FLASH therapy. Production of mini-beams, and operation with multiple ions for imaging and treatment are also considered. This accelerator is intended to become the main element of a facility devoted to a programme of cancer research and treatment with proton and helium beams, to both cure patients and contribute to the assessment of helium beams as a new tool to fight cancer.

Slides TUOZGD2 [1.940 MB]

DOI •

reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2022-TUOZGD2

About •

Received ※ 20 May 2022 — Revised ※ 11 June 2022 — Accepted ※ 16 June 2022 — Issue date ※ 11 July 2022

Cite •

reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

THPOMS022

Production of Radioisotopes for Cancer Imaging and Treatment with Compact Linear Accelerators

2996

M. Vretenar, A. Mamaras
CERN, Meyrin, Switzerland
G. Bisoffi
INFN/LNL, Legnaro (PD), Italy
P. Foka
GSI, Darmstadt, Germany

Accelerator-produced radioisotopes are widely used in modern medicine, for imaging, for cancer therapy, and for combinations of therapy and diagnostics. Clinical trials are well advanced for several radioisotope-based treatments that might open the way to a strong request of specific accelerator systems dedicated to radioisotope production. While cyclotrons are the standard tool in this domain, we explore here alternative options using linear accelerators. Compared to cyclotrons, linacs have the advantage of modularity, compactness, and reduced beam loss with lower shielding requirements. Although in general more expensive than cyclotrons, linacs are competitive in cost for production of low-energy proton beams, or of intense beams of heavier particles. After a review of radioisotopes of potential interest, in particular those produced with low-energy protons or helium, this paper presents two linac-based isotope production systems. The first is a compact RFQ-based system for PET isotopes, and the second is an alpha-particle linac for production of alpha-emitters. The accelerator systems are described, together with calculations of production yields for different targets.

DOI •

reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2022-THPOMS022

About •

Received ※ 20 May 2022 — Revised ※ 15 June 2022 — Accepted ※ 16 June 2022 — Issue date ※ 17 June 2022

Cite •

reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

THPOMS049

Energy Comparison of Room Temperature and Superconducting Synchrotrons for Hadron Therapy

3080

G. Bisoffi
INFN/LNL, Legnaro (PD), Italy
E. Benedetto, M. Karppinen, M.R. Khalvati, M. Vretenar, R. van Weelderen
CERN, Meyrin, Switzerland
M.G. Pullia, G. Venchi
CNAO Foundation, Pavia, Italy
L. Rossi
INFN/LASA, Segrate (MI), Italy
M. Sapinski
PSI, Villigen PSI, Switzerland
M. Sorbi
Universita’ degli Studi di Milano & INFN, Segrate, Italy
R.U. Valente
La Sapienza University of Rome, Rome, Italy

The yearly energy requirements of normal conducting (NC) and superconducting (SC) magnet options of a new hadron therapy (HT) facility are compared. Special reference is made to the layouts considered for the proposed SEEIIST facility. Benchmarking with the NC CNAO HT centre in Pavia (Italy) was carried out. The energy comparison is centred on the different synchrotron solutions, assuming the same injector and lines in the designs. The beam current is more than a factor 10 higher with respect to present generation facilities. This allows efficient ’multi-energy extraction’ (MEE), which shortens the therapy treatment and is needed especially in the SC option, because of the slow magnet ramping time. Hence, power values of the facility in the traditional mode were converted into MEE ones, for the sake of a fair stepwise comparison between NC and SC magnets. The use of cryocoolers and a liquefier are also compared, for synchrotron refrigeration. This study shows that a NC facility operated in MEE mode requires the least average energy, followed by the SC synchrotron solution with a liquefier, while the most energy intensive solution is the SC one with cryocoolers.

DOI •

reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2022-THPOMS049

About •

Received ※ 20 May 2022 — Revised ※ 17 June 2022 — Accepted ※ 28 June 2022 — Issue date ※ 10 July 2022

Cite •

reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)