Author: Yap, J.S.L.
Paper Title Page
MOPAB418 Tracking and LET Measurements with the MiniPIX-TimePIX Detector for 60 MeV Clinical Protons 1260
 
  • J.S.L. Yap, C.P. Welsch
    Cockcroft Institute, Warrington, Cheshire, United Kingdom
  • N.J.S. Bal
    NIKHEF, Amsterdam, The Netherlands
  • M.D. Brooke
    University of Oxford, Oxford, United Kingdom
  • C. Granja, C. Oancea
    ADVACAM s.r.o, Prague, Czech Republic
  • A. Kacperek
    The Douglas Cyclotron, The Clatterbridge Cancer Centre NHS Foundation Trust, Wirral, United Kingdom
  • C.P. Welsch, J.S.L. Yap
    The University of Liverpool, Liverpool, United Kingdom
  
  Funding: EU FP7 grant agreement 215080, H2020 Marie Sklodowska-Curie grant agreement No 675265, OMA - Optimization of Medical Accelerators and the Cockcroft Institute core grant STGA00076-01.
Re­cent ad­vance­ments in ac­cel­er­a­tor tech­nol­ogy have led the rapid emer­gence of par­ti­cle ther­apy fa­cil­i­ties world­wide, af­firm­ing the need for en­hanced char­ac­ter­i­sa­tion meth­ods of ra­di­a­tion fields and ra­dio­bi­o­log­i­cal ef­fects. The Clat­ter­bridge Can­cer Cen­tre, UK op­er­ates a 60 MeV pro­ton beam to treat oc­u­lar can­cers and fa­cil­i­tates stud­ies into pro­ton in­duced ra­dio­bi­o­log­i­cal re­sponses. Ac­cord­ingly, an in­di­ca­tor of ra­di­a­tion qual­ity is the lin­ear en­ergy trans­fer (LET), a chal­leng­ing phys­i­cal quan­tity to mea­sure. The MiniPIX-Timepix is a minia­turised, hy­brid semi­con­duc­tor pixel de­tec­tor with a Timepix ASIC, en­abling wide-range mea­sure­ments of the de­posited en­ergy, po­si­tion and di­rec­tion of in­di­vid­ual charged par­ti­cles. High res­o­lu­tion spec­tro­met­ric track­ing and si­mul­ta­ne­ous en­ergy mea­sure­ments of sin­gle par­ti­cles en­able the beam pro­file, time, spa­tial dose map­ping and LET (0.1 to >100 keV/µm) to be re­solved. Mea­sure­ments were per­formed to de­ter­mine the LET spec­tra in sil­i­con, at dif­fer­ent po­si­tions along the Bragg Peak (BP). We dis­cuss the ex­per­i­men­tal setup, pre­lim­i­nary re­sults and ap­plic­a­bil­ity of the MiniPIX for clin­i­cal en­vi­ron­ments. 		 
DOI • reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2021-MOPAB418  
About • paper received ※ 18 May 2021       paper accepted ※ 23 July 2021       issue date ※ 25 August 2021  
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MOPAB417 Preliminary Study of a Large Energy Acceptance FFA Beam Delivery System for Particle Therapy 1256
 
  • J.S.L. Yap, E.R. Higgins, S.L. Sheehy
    The University of Melbourne, Melbourne, Victoria, Australia
  
  The avail­abil­ity and use of ion beams for ra­dio­ther­apy has grown sig­nif­i­cantly, led by tech­no­log­i­cal de­vel­op­ments to ex­ploit the dosi­met­ric ad­van­tages of­fered by charged par­ti­cles. The ben­e­fits of par­ti­cle ther­apy (PT) are well iden­ti­fied how­ever its util­i­sa­tion is still lim­ited by high fa­cil­ity costs and tech­no­log­i­cal chal­lenges. A pos­si­bil­ity to ad­dress both of these can be con­sid­ered by im­prove­ments to the beam de­liv­ery sys­tem (BDS). Ex­ist­ing beam­lines and gantries trans­port beams with a mo­men­tum range of ±1% and con­se­quently, ad­just­ments in depth or beam en­ergy re­quire all the mag­netic fields to be changed. The speed to switch en­er­gies is a lim­it­ing con­straint of the BDS and a de­ter­mi­nant of the over­all treat­ment time. A novel con­cept using fixed field al­ter­nat­ing gra­di­ent (FFA) op­tics en­ables a large en­ergy ac­cep­tance (LEA) as beams of vary­ing en­er­gies can tra­verse the beam­line at mul­ti­ple phys­i­cal po­si­tions given the same mag­netic field. This pre­sents the po­ten­tial to pro­vide faster, higher qual­ity treat­ments at lower costs, with the ca­pa­bil­ity to de­liver ad­vanced PT tech­niques such as multi-ion ther­apy. We ex­plore the ap­plic­a­bil­ity and ben­e­fits of a LEA BDS.  
DOI • reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2021-MOPAB417  
About • paper received ※ 18 May 2021       paper accepted ※ 27 July 2021       issue date ※ 15 August 2021  
Export • reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)