IBIC2023 - List of Authors (Denker, A.)

Paper	Title	Page
MOP002	MiniBEE - Minibeam Beamline for Preclinical Experiments	34
	J. Reindl, G. Datzmann, G. Dollinger, J. Neubauer, A. Rousseti Universität der Bundeswehr Muenchen, Neubiberg, Germany J. Bundesmann, A. Denker, A. Dittwald, G. Kourkafas HZB, Berlin, Germany G. Datzmann Datzmann Interact & Innovate GmbH, München, Germany A. Denker BHT, Berlin, Germany
	Spatial fractionated radiotherapy using protons, so-called proton minibeam radiotherapy (pMBT) was developed for better sparing of normal tissue in the entrance channel of radiation. Progressing towards clinical use, pMBT should overcome current technical and biomedical limitations. This work discusses a preclinical pMBT facility, currently built at the 68.5MeV cyclotron at the Helmholtz Zentrum Berlin. The goal is to irradiate small animals using focused pMBT with a σ of 50µm, a high peak-to-valley dose ratio at center-to-center distance as small as 1mm and beam current of 1nA. A first degrader defines the maximum energy of the beam. Dipole magnets and quadrupole triplets transport the beam to the treatment room while multiple slits properly form the transverse beam profiles. A high magnetic field gradient triplet lens forms the minibeams in front of the target station and, scanning magnets are used for a raster scan at the target. An additional degrader, positioned close before the focusing spot and the target, further reduces the energy, forming a spread-out Bragg peak. A small animal radiation research platform will be used for imaging and positioning of the target.
DOI •	reference for this paper ※ doi:10.18429/JACoW-IBIC2023-MOP002
About •	Received ※ 09 September 2023 — Revised ※ 14 September 2023 — Accepted ※ 25 September 2023 — Issue date ※ 29 September 2023
Cite •	reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

Paper

Title

Page

MiniBEE - Minibeam Beamline for Preclinical Experiments

34

J. Reindl, G. Datzmann, G. Dollinger, J. Neubauer, A. Rousseti
Universität der Bundeswehr Muenchen, Neubiberg, Germany
J. Bundesmann, A. Denker, A. Dittwald, G. Kourkafas
HZB, Berlin, Germany
G. Datzmann
Datzmann Interact & Innovate GmbH, München, Germany
A. Denker
BHT, Berlin, Germany

Spatial fractionated radiotherapy using protons, so-called proton minibeam radiotherapy (pMBT) was developed for better sparing of normal tissue in the entrance channel of radiation. Progressing towards clinical use, pMBT should overcome current technical and biomedical limitations. This work discusses a preclinical pMBT facility, currently built at the 68.5MeV cyclotron at the Helmholtz Zentrum Berlin. The goal is to irradiate small animals using focused pMBT with a σ of 50µm, a high peak-to-valley dose ratio at center-to-center distance as small as 1mm and beam current of 1nA. A first degrader defines the maximum energy of the beam. Dipole magnets and quadrupole triplets transport the beam to the treatment room while multiple slits properly form the transverse beam profiles. A high magnetic field gradient triplet lens forms the minibeams in front of the target station and, scanning magnets are used for a raster scan at the target. An additional degrader, positioned close before the focusing spot and the target, further reduces the energy, forming a spread-out Bragg peak. A small animal radiation research platform will be used for imaging and positioning of the target.

DOI •

reference for this paper ※ doi:10.18429/JACoW-IBIC2023-MOP002

About •

Received ※ 09 September 2023 — Revised ※ 14 September 2023 — Accepted ※ 25 September 2023 — Issue date ※ 29 September 2023

Cite •

reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)