Cyclotrons2019 - List of Authors (Bundesmann, J.)

Paper	Title	Page
TUP007	Operational Experience in the Treatment of Ocular Melanomas with a New Digital Low-level RF Control System	162
	T. Fanselow, J. Bundesmann, A. Denker, U. Hiller HZB, Berlin, Germany J.K. Abraham, J.L. Conradie, W. Duckitt iThemba LABS, Somerset West, South Africa
	Ocular melanomas have been treated for the last 20 years at the Helmholtz-Zentrum Berlin in collaboration with the Charité Universitätsmedizin Berlin. However, parts of the initial control system electronics date back to the 1970s, when the machine was installed. Facing a critical shortage of legacy and obsolete components and with the down-time due to failures in the electronics on the increase, a decision was made to install the digital low-level RF control system, developed by iThemba LABS, on our K=132 cyclotron. A short description of the installation and commissioning process, which occurred in April 2017, and the experiences of the first 2 years of operation with the new digital low-level RF control system is presented.
DOI •	reference for this paper ※ https://doi.org/10.18429/JACoW-Cyclotrons2019-TUP007
About •	paper received ※ 14 September 2019 paper accepted ※ 25 September 2019 issue date ※ 20 June 2020
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TUP020	Beam Properties at the Experimental Target Station of the Proton Therapy in Berlin	199
	J. Bundesmann, A. Denker, J. Holz auf der Heide HZB, Berlin, Germany
	Beside the Therapy station for ocular tumors we have an experimental area to deliver protons and other ions. At this place there is also the possibility to do High Energy Pixe measurements on samples from cultural heritage. The positioning of the samples under test is possible by means of an xy-table with an range of 500x500 mm² and a load of at least 50 kg, reproducibility ±0.1 mm. We can change the beam size between 1 mm diameter as focused beam and up to 50 mm diameter with different scattering foils and homogeneous dose spread. We can deliver beam intensities from single protons up to 10¹² protons/cm² * sec The energy can be set to 68 MeV with a single Bragg peak, spread out Bragg peaks with a mechanical range shifter or absorber plates to reduce the energy. The timing properties range from quasi DC to a single pulse width of 1 ns with a repetition rate up to 2.4 MHz. Instead of a scattering foil to increase the beam spots we also can use beam scanning with the focused beam to reduce the beam losses. We will show the different beam properties at the experimental target area for radiation hardness testing of solar cells, optical elements and electronics under test.
DOI •	reference for this paper ※ https://doi.org/10.18429/JACoW-Cyclotrons2019-TUP020
About •	paper received ※ 14 September 2019 paper accepted ※ 25 September 2019 issue date ※ 20 June 2020
Export •	reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

TUP021	Towards FLASH Proton Irradiation at HZB	202
	G. Kourkafas, J. Bundesmann, A. Denker, T. Fanselow, J. Röhrich HZB, Berlin, Germany V.H. Ehrhardt, J. Gollrad, J. Heufelder, A. Weber Charite, Berlin, Germany
	The HZB cyclotron has been providing protons for eye-tumor treatment for more than 20 years. While it has been very successful using conventional dose rates (15-20 Gy/min), recent studies indicate that rapid irradiation with very high dose rates (FLASH) might be equally efficient against tumors but less harmful to healthy tissues. The flexible operation schemes of the HZB cyclotron can provide beams with variable intensities and time structures, covering a wide unexplored regime within the FLASH requirements (>40 Gy/s in <500 ms). This paper presents the results of the first FLASH beam production at HZB towards the establishment of an in-vivo clinical irradiation in the future.
	Poster TUP021 [1.031 MB]
DOI •	reference for this paper ※ https://doi.org/10.18429/JACoW-Cyclotrons2019-TUP021
About •	paper received ※ 12 September 2019 paper accepted ※ 25 September 2019 issue date ※ 20 June 2020
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TUC02	Status of the HZB Cyclotron	253
	A. Denker, J. Bundesmann, T. Damerow, T. Fanselow, D. Hildebrand, U. Hiller, I. Kailouh, G. Kourkafas, S. Ozierenski, C. Rethfeldt, J. Röhrich, S. Seidel, C. Zimmer HZB, Berlin, Germany D. Cordini, J. Heufelder, R. Stark, A. Weber Charite, Berlin, Germany
	For more than 20 years eye tumours are treated in collaboration with the Charité - Universitätsmedizin Berlin. The close co-operation between Charité and HZB permits joint interdisciplinary research. Irradiations with either a sharp, well focused or a broad beam, either in vacuum or in air are possible. In addition, a 60Co-source for gamma-irradiations is available. Experiments now comprise dosimetry, detector comparisons, ambulant mouse irradiations, including class I gene-modified mice. Furthermore, radiation hardness tests on detectors, CCD-cameras and other electronics are performed. In order to improve the beam diagnosis between the 2 MV injector Tandetron and the cyclotron a harp has been installed, leading to new beam line calculations for the injection line. The accelerator operation for therapy as well as on-going experiments and results will be presented.
	Slides TUC02 [1.965 MB]
DOI •	reference for this paper ※ https://doi.org/10.18429/JACoW-Cyclotrons2019-TUC02
About •	paper received ※ 14 September 2019 paper accepted ※ 25 September 2019 issue date ※ 20 June 2020
Export •	reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

Paper

Title

Page

Operational Experience in the Treatment of Ocular Melanomas with a New Digital Low-level RF Control System

162

T. Fanselow, J. Bundesmann, A. Denker, U. Hiller
HZB, Berlin, Germany
J.K. Abraham, J.L. Conradie, W. Duckitt
iThemba LABS, Somerset West, South Africa

Ocular melanomas have been treated for the last 20 years at the Helmholtz-Zentrum Berlin in collaboration with the Charité Universitätsmedizin Berlin. However, parts of the initial control system electronics date back to the 1970s, when the machine was installed. Facing a critical shortage of legacy and obsolete components and with the down-time due to failures in the electronics on the increase, a decision was made to install the digital low-level RF control system, developed by iThemba LABS, on our K=132 cyclotron. A short description of the installation and commissioning process, which occurred in April 2017, and the experiences of the first 2 years of operation with the new digital low-level RF control system is presented.

DOI •

reference for this paper ※ https://doi.org/10.18429/JACoW-Cyclotrons2019-TUP007

About •

paper received ※ 14 September 2019 paper accepted ※ 25 September 2019 issue date ※ 20 June 2020

Export •

reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

TUP020

Beam Properties at the Experimental Target Station of the Proton Therapy in Berlin

199

J. Bundesmann, A. Denker, J. Holz auf der Heide
HZB, Berlin, Germany

Beside the Therapy station for ocular tumors we have an experimental area to deliver protons and other ions. At this place there is also the possibility to do High Energy Pixe measurements on samples from cultural heritage. The positioning of the samples under test is possible by means of an xy-table with an range of 500x500 mm² and a load of at least 50 kg, reproducibility ±0.1 mm. We can change the beam size between 1 mm diameter as focused beam and up to 50 mm diameter with different scattering foils and homogeneous dose spread. We can deliver beam intensities from single protons up to 10¹² protons/cm² * sec The energy can be set to 68 MeV with a single Bragg peak, spread out Bragg peaks with a mechanical range shifter or absorber plates to reduce the energy. The timing properties range from quasi DC to a single pulse width of 1 ns with a repetition rate up to 2.4 MHz. Instead of a scattering foil to increase the beam spots we also can use beam scanning with the focused beam to reduce the beam losses. We will show the different beam properties at the experimental target area for radiation hardness testing of solar cells, optical elements and electronics under test.

DOI •

reference for this paper ※ https://doi.org/10.18429/JACoW-Cyclotrons2019-TUP020

About •

paper received ※ 14 September 2019 paper accepted ※ 25 September 2019 issue date ※ 20 June 2020

Export •

reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

TUP021

Towards FLASH Proton Irradiation at HZB

202

G. Kourkafas, J. Bundesmann, A. Denker, T. Fanselow, J. Röhrich
HZB, Berlin, Germany
V.H. Ehrhardt, J. Gollrad, J. Heufelder, A. Weber
Charite, Berlin, Germany

The HZB cyclotron has been providing protons for eye-tumor treatment for more than 20 years. While it has been very successful using conventional dose rates (15-20 Gy/min), recent studies indicate that rapid irradiation with very high dose rates (FLASH) might be equally efficient against tumors but less harmful to healthy tissues. The flexible operation schemes of the HZB cyclotron can provide beams with variable intensities and time structures, covering a wide unexplored regime within the FLASH requirements (>40 Gy/s in <500 ms). This paper presents the results of the first FLASH beam production at HZB towards the establishment of an in-vivo clinical irradiation in the future.

Poster TUP021 [1.031 MB]

DOI •

reference for this paper ※ https://doi.org/10.18429/JACoW-Cyclotrons2019-TUP021

About •

paper received ※ 12 September 2019 paper accepted ※ 25 September 2019 issue date ※ 20 June 2020

Export •

reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

TUC02

Status of the HZB Cyclotron

253

A. Denker, J. Bundesmann, T. Damerow, T. Fanselow, D. Hildebrand, U. Hiller, I. Kailouh, G. Kourkafas, S. Ozierenski, C. Rethfeldt, J. Röhrich, S. Seidel, C. Zimmer
HZB, Berlin, Germany
D. Cordini, J. Heufelder, R. Stark, A. Weber
Charite, Berlin, Germany

For more than 20 years eye tumours are treated in collaboration with the Charité - Universitätsmedizin Berlin. The close co-operation between Charité and HZB permits joint interdisciplinary research. Irradiations with either a sharp, well focused or a broad beam, either in vacuum or in air are possible. In addition, a 60Co-source for gamma-irradiations is available. Experiments now comprise dosimetry, detector comparisons, ambulant mouse irradiations, including class I gene-modified mice. Furthermore, radiation hardness tests on detectors, CCD-cameras and other electronics are performed. In order to improve the beam diagnosis between the 2 MV injector Tandetron and the cyclotron a harp has been installed, leading to new beam line calculations for the injection line. The accelerator operation for therapy as well as on-going experiments and results will be presented.

Slides TUC02 [1.965 MB]

DOI •

reference for this paper ※ https://doi.org/10.18429/JACoW-Cyclotrons2019-TUC02

About •

paper received ※ 14 September 2019 paper accepted ※ 25 September 2019 issue date ※ 20 June 2020

Export •

reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)