| Paper | Title | Page |
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| TUA03 | The Use of PSI’s IP2 Beam Line Towards Exotic Radionuclide Development and its Application Towards Proof-Of-Principle Preclinical and Clinical Studies | 132 |
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Paul Scherrer Institute runs a High Intensity Proton Accelerator (HIPA) facility, where a maximum of 100 µA protons is gleaned from high intensity 72 MeV protons from Injector 2, a separated sector cyclotron, into the IP2 target station. These protons irradiate various targets towards the production of exotic radionuclides intended for medical purposes. Many radiometals in use today are for the diagnosis of disease, with the most popular means of detection being Positron Emission Tomography. These positron emitters are easily produced at low proton energies using medical cyclotrons, however, development at these facilities are lacking. The 72 MeV proton beam is degraded at IP2 using niobium to provide the desired energy to irradiate targets to produce the likes of 44Sc, 43Sc, 64Cu and 165Er*,**,***. Once developed, these proofs-of-principle are then put into practice at partner facilities. Target holders and degraders require development to optimize irradiation conditions and target cooling. Various options are explored, with pros and cons taken into consideration based on calculations and simulations.
* v/d Meulen et al., Nucl Med. Biol. (2015) 42: 745 ** Domnanich et al., EJNMMI Radiopharm. Chemistry (2017) 2: 14 *** v/d Meulen et al., J Label Compd Radiopharm (2019) doi: 10.1002/jlcr.3730 |
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Slides TUA03 [7.449 MB] | |
| DOI • | reference for this paper ※ https://doi.org/10.18429/JACoW-Cyclotrons2019-TUA03 | |
| About • | paper received ※ 13 September 2019 paper accepted ※ 26 September 2019 issue date ※ 20 June 2020 | |
| Export • | reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml) | |
| TUA02 | Novel Irradiation Methods for Theranostic Radioisotope Production With Solid Targets at the Bern Medical Cyclotron | 127 |
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| The production of medical radioisotopes for theranostics is essential for the development of personalized nuclear medicine. Among them, radiometals can be used to label proteins and peptides and their supply in quantity and quality for clinical applications represents a challenge. A research program is ongoing at the Bern medical cyclotron, where a solid target station with a pneumatic delivery system is in operation. To bombard isotope-enriched materials in form of compressed powders, a specific target coin was realized. To assess the activity at EoB, a system based on a CZT detector was developed. For an optimized production yield with the required radio nuclide purity, precise knowledge of the cross-sections and of the beam energy is crucial. Specific methods were developed to assess these quantities. To further enhance the capabilities of solid target stations at medical cyclotrons, a novel irradiation system based on an ultra-compact ~50 cm long beam line and a two-dimensional beam monitoring detector is under development to bombard targets down to few mg and few mm diameter. The first results on the production of Ga-68, Cu-64, Sc-43, Sc-44 and Sc-47 are presented. | ||
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Slides TUA02 [37.771 MB] | |
| DOI • | reference for this paper ※ https://doi.org/10.18429/JACoW-Cyclotrons2019-TUA02 | |
| About • | paper received ※ 13 September 2019 paper accepted ※ 25 September 2019 issue date ※ 20 June 2020 | |
| Export • | reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml) | |