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TY - CONF AU - van der Meulen, N.P. AU - Braccini, S. AU - Eichler, R. AU - Grundler, P.V. AU - Hasler, R. AU - Hirzel, W. AU - Joray, S. AU - Kiselev, D.C. AU - Sobbia, R. AU - Sommerhalder, A. AU - Talip, Z. AU - Zhang, H. ED - Conradie, Lowry ED - De Villiers, John Garrett ED - Schaa, Volker RW TI - The Use of PSI’s IP2 Beam Line Towards Exotic Radionuclide Development and its Application Towards Proof-Of-Principle Preclinical and Clinical Studies J2 - Proc. of Cyclotrons2019, Cape Town, South Africa, 23-27 September 2019 CY - Cape Town, South Africa T2 - International Conference on Cyclotrons and their Applications T3 - 22 LA - english AB - Paul Scherrer Institute runs a High Intensity Proton Accelerator (HIPA) facility, where a maximum of 100 µA protons is gleaned from high intensity 72 MeV protons from Injector 2, a separated sector cyclotron, into the IP2 target station. These protons irradiate various targets towards the production of exotic radionuclides intended for medical purposes. Many radiometals in use today are for the diagnosis of disease, with the most popular means of detection being Positron Emission Tomography. These positron emitters are easily produced at low proton energies using medical cyclotrons, however, development at these facilities are lacking. The 72 MeV proton beam is degraded at IP2 using niobium to provide the desired energy to irradiate targets to produce the likes of 44Sc, 43Sc, 64Cu and 165Er*,**,***. Once developed, these proofs-of-principle are then put into practice at partner facilities. Target holders and degraders require development to optimize irradiation conditions and target cooling. Various options are explored, with pros and cons taken into consideration based on calculations and simulations. PB - JACoW Publishing CP - Geneva, Switzerland SP - 132 EP - 135 KW - target KW - proton KW - cyclotron KW - radiation KW - positron DA - 2020/06 PY - 2020 SN - 978-3-95450-205-9 DO - doi:10.18429/JACoW-Cyclotrons2019-TUA03 UR - http://jacow.org/cyclotrons2019/papers/tua03.pdf ER -