JACoW is a publisher in Geneva, Switzerland that publishes the proceedings of accelerator conferences held around the world by an international collaboration of editors.
TY - CONF AU - Verkhovod, G.D. AU - Kasatov, D.A. AU - Kolesnikov, Ia.A. AU - Makarov, A.N. AU - Savinov, S. AU - Shchudlo, I.M. AU - Sycheva, T. AU - Taskaev, S.Yu. ED - Kuzin, Maksim V. ED - Schaa, Volker RW TI - Verification of a Beam of Epithermal Neutrons for Boron-Neutron Capture Therapy J2 - Proc. of RuPAC2021, Alushta, Crimea, 27 September-01 October 2021 CY - Alushta, Crimea T2 - Russian Particle Accelerator Conference T3 - 27 LA - english AB - At Budker Institute of Nuclear Physics it was proposed and developed a source of epithermal neutrons based on a tandem accelerator with vacuum insulation and a lithium target for the development of boron neutron capture therapy, a promising method for treating malignant tumors. To measure the "boron" dose due to the boron-lithium reaction, a small-sized detector has been developed. It consists of two polystyrene scintillators, one of which is enriched with boron. Using the detector, the spatial distribution of boron dose and dose of gamma radiation in a 330x330x315 mm water phantom was measured and the results obtained were compared with the results of numerical simulation of the absorbed dose components in such a tissue-equivalent phantom. It is shown that the results obtained are in good agreement with the calculated ones. It was found that the use of a 72 mm Plexiglas moderator provides an acceptable quality of the neutron beam for in vitro and in vivo studies, namely: 1 mA 2.05 MeV proton beam on a lithium target provides a dose rate of 30 Gy-Eq/h in cells containing boron at a concentration of 40 ppm, and 6 Gy-Eq/h in cells without boron. The developed technique for on-line measurement of boron dose and dose of gamma radiation makes it possible to carry out a similar verification of a neutron beam prepared for clinical trials of BNCT after placing a neutron beam shaping assembly with a magnesium fluoride moderator in a bunker adjacent to the accelerator. PB - JACoW Publishing CP - Geneva, Switzerland SP - 199 EP - 201 KW - neutron KW - radiation KW - proton KW - detector KW - experiment DA - 2021/10 PY - 2021 SN - 2673-5539 SN - 978-3-95450-240-0 DO - doi:10.18429/JACoW-RuPAC2021-MOPSA47 UR - https://jacow.org/rupac2021/papers/mopsa47.pdf ER -