Author: Sycheva, T.
Paper Title Page
THCEMH01 Vacuum Insulation Tandem Accelerator: Progress and Prospects 147
 
  • S.Yu. Taskaev, A.A. Ivanov, D.A. Kasatov, A.N. Makarov, Y.M. Ostreinov, I.M. Shchudlo, I.N. Sorokin, T. Sycheva
    BINP SB RAS, Novosibirsk, Russia
  • T.A. Bykov
    Budker INP & NSU, Novosibirsk, Russia
  • A.A. Ivanov, Ya.A. Kolesnikov, A.M. Koshkarev, E.O. Sokolova, S.Yu. Taskaev
    NSU, Novosibirsk, Russia
  
  Funding: The study was supported by the grants from the Ministry of Science of the Russian Federation, the Russian Science Foundation, Budker Institute of Nuclear Physics and Novosibirsk State University.
A promising method of treatment of many malignant tumors is the boron neutron capture therapy (BNCT)*. It provides a selective destruction of tumor cells by prior accumulation of a stable boron-10 isotope inside them and subsequent irradiation with epithermal neutrons. It is expected that accelerator based neutron sources will be created for the clinical practice. One such source could be an original source of epithermal neutrons**, created in BINP. To obtain proton beam a new type of particle accelerator is used - tandem accelerator with vacuum insulation. Generation of neutrons is carried out as a result of the threshold reaction 7Li(p, n)7Be. During 2015-2016 in the construction of tandem accelerator with vacuum insulation several changes were made. This allowed us to suppress the unwanted flow of charged particles in the accelerator, to improve its high-voltage stability, and to increase the proton beam current from 1.6 to 5 mA. Such current value is sufficient for BNCT. The report describes in detail the modernization of the accelerator, presents and discusses the results of experiments on obtaining the proton beam and the formation of neutron flux using lithium target, and declares our prospective plans. The obtained neutron beam meets the requirements of BNCT: the irradiation of cell cultures provides the destruction of cells with boron and preservation of cells without boron. Irradiation of immunodeficient mice with grafted glioblastoma results in their recovery.
*Neutron Capture Therapy. Principles and Applications. Eds: W. Sauerwein, A. Wittig, R. Moss, Y. Nakagawa. Springer, 2012.
**S. Taskaev. Accelerator based epithermal neutron source. Physics of Particles and Nuclei 46 (2015) 956-990. 		 
slides icon Slides THCEMH01 [7.616 MB]  
Export • reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)  
 
WEPSB048 Beam Shaping Assembly Optimization for Boron Neutron Capture Therapy 471
 
  • T. Sycheva, S.Yu. Taskaev
    BINP SB RAS, Novosibirsk, Russia
  • S.A. Frolov, S.I. Lezhnin
    NSI RAS, Moscow, Russia
  
  Epithermal neutron source, based on vacuum insulation tandem accelerator and lithium target, has been developed and is now in use in the Budker Institute of Nuclear Physics. Neutrons are generated in 7Li(p, n)7Be reaction under proton energies from 2 to 2.5 MeV. A beam shaping assembly (BSA) for therapeutic neutron beam forming is used. It includes moderator, reflector, and absorber. In this work the simulation results of the depth dose rate distribution in modified Snyder head phantom for a range of neutron energies are presented and discussed. Variants of BSA optimization depending on tumor depth are proposed. The calculations were carried out by Monte-Carlo neutron and photon transport code NMC. Our research revealed that high quality neutron beam generation may be obtained with proton energy of 2.3 MeV. Discovered optimal schemes of BSA including sizes and materials are presented and discussed.  
Export • reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)