Author: de Oliveira, H.B.
Paper Title Page
MOPAB409 FLUKA Simulations of 225Ac Production Using Electron Accelerators: Validation Through Comparison with Published Experiments 1226
 
  • T.V. Szabo, I.C. Moraes
    CNPEM, Campinas, SP, Brazil
  • F.A. Bacchim Neto
    LNLS, Campinas, Brazil
  • P.V. Guillaumon
    USP/LAL, Sao Paulo, Brazil
  • H.B. de Oliveira
    IPEN, São Paulo, Brazil
 
  Tar­geted Alpha Ther­apy (TAT) is an ac­tive area of study world­wide. This tech­nique has shown a po­ten­tial in nu­clear med­i­cine to treat metasta­tic dis­ease by alpha par­ti­cles that de­posit en­ergy in small re­gions nearby can­cer cells. Ac-225 is an im­por­tant al­pha-emit­ting that can be used for can­cer TAT. This ra­dioiso­tope shows good po­ten­tial for med­ical ap­pli­ca­tions, there­fore is im­por­tant to study ways of in­crease its pro­duc­tion and avail­abil­ity. One pos­si­ble path for the Ac-225 prod­uct is to ra­di­ate a ra­dium tar­get (Ra-226) on a lin­ear elec­tron ac­cel­er­a­tor (LINAC). Iso­tope pro­duc­tion stud­ies could be im­ple­mented using com­pu­ta­tional tools. In this work, Monte Carlo sim­u­la­tions with FLUKA code were per­formed and com­pared to ex­per­i­men­tal re­sults *. We stud­ied Ac-225 pro­duc­tion by pho­tonu­clear re­ac­tions using a 24 MeV elec­tron beam LINAC hit­ting a tung­sten elec­tron-pho­ton con­verter. Dif­fer­ent en­er­gies and geome­tries were also sim­u­lated to ob­tain op­ti­mal pro­duc­tion con­di­tions. The spe­cific ac­tiv­ity val­ues ob­tained with sim­u­la­tions had a good agree­ment with pub­lished ex­per­i­men­tal re­sults.
* MASLOV, O., et. al. Preparation of 225Ac by 226Ra(g, n) photonuclear reaction on an mt25 microtron. Radiochemistry
 
DOI • reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2021-MOPAB409  
About • paper received ※ 19 May 2021       paper accepted ※ 09 June 2021       issue date ※ 30 August 2021  
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