IPAC2019 - List of Authors (Angal-Kalinin, D.)

Paper	Title	Page
THPMP041	A Comparative Study of Biological Effects of Electrons and Co-60 Gamma Rays on pBR322 Plasmid DNA	3533
SUSPFO119	use link to see paper's listing under its alternate paper code
	K.L. Small, R.M. Jones UMAN, Manchester, United Kingdom D. Angal-Kalinin, M. Surman Cockcroft Institute, Warrington, Cheshire, United Kingdom A. Chadwick, N.T. Henthorn, K. Kirkby, M.J. Merchant, R. Morris, E. Santina The Christie NHS Foundation Trust, Manchester, United Kingdom R. Edge Dalton Cumbrian Facility, University of Manchester, Cumbria, United Kingdom R.J. Smith STFC/DL/ASTeC, Daresbury, Warrington, Cheshire, United Kingdom
	Very High-Energy Electron (VHEE) therapy is a rapidly developing field motivated by developments in high-gradient linacs. Advantages include sufficient penetration (>30 cm) for treatment of deep-seated tumours, measured insensitivity to inhomogeneities and rapid delivery time, making VHEE viable for treatment of heterogeneous regions, e.g. lung or bowel. Researchers at the University of Manchester and CERN have routinely produced accelerating gradients of ~100 MeV/m for the CLIC project. Suitable modification can result in a high gradient medical linac producing 250 MeV electrons within a treatment room. Radiobiological research for VHEE is vital to understand its use in radiotherapy and how it compares with conventional modalities. The goal of radiotherapy is to destroy tumour cells while sparing healthy cells, primarily by damaging DNA within the cancer cell. The study aim is to understand the fundamental interactions between VHEE and biological structures through plasmid irradiation studies - both computational, using the Monte Carlo GEANT4-DNA code, and experimental. Plasmid irradiation experiments have been carried out at using Co-60 gammas at the Dalton Cumbrian Facility and using 6-15 MeV electrons at the Christie NHS Foundation Trust to determine the type and quantity of damage caused to DNA by electron irradiation. These experiments are a world first in VHEE radiobiology, with further studies planned at higher energies using the CLARA and CLEAR facilities at Daresbury and CERN. These studies will also consider the effective dose range of VHEE with energy, as well as implications of damage on DNA. Research into this area of radiotherapy can provide a valuable addition to tools currently available to physicians in the fight against cancer.
DOI •	reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2019-THPMP041
About •	paper received ※ 15 May 2019 paper accepted ※ 22 May 2019 issue date ※ 21 June 2019
Export •	reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

TUPGW008	PERLE: A High Power Energy Recovery Facility	1396
	W. Kaabi, I. Chaikovska, A. Stocchi, C. Vallerand LAL, Orsay, France D. Angal-Kalinin, J.W. McKenzie, B.L. Militsyn, P.H. Williams STFC/DL/ASTeC, Daresbury, Warrington, Cheshire, United Kingdom S.A. Bogacz, A. Hutton, F. Marhauser, R.A. Rimmer, C. Tennant JLab, Newport News, Virginia, USA S. Bousson, D. Longuevergne, G. Olivier, G. Olry IPN, Orsay, France O.S. Brüning, R. Calaga, L. Dassa, F. Gerigk, E. Jensen, P.A. Thonet CERN, Geneva, Switzerland B. Hounsell, M. Klein, C.P. Welsch The University of Liverpool, Liverpool, United Kingdom E.B. Levichev, Yu.A. Pupkov BINP SB RAS, Novosibirsk, Russia
	PERLE is a proposed high power Energy Recovery Linac, designed on multi-turn configuration, based on SRF technology, to be hosted at Orsay-France in a col-laborative effort between local laboratories: LAL and IPNO, together with an international collaboration involv-ing today: CERN, JLAB, STFC ASTeC Daresbury, Liverpool University and BINP Novosibirsk. PERLE will be a unique leading edge facility designed to push advances in accelerator technology, to provide intense and highly flexible test beams for component development. In its final configuration, PERLE provides a 500 MeV elec-tron beam using high current (20 mA) acceleration during three passes through 801.6 MHz cavities. This presenta-tion outlines the technological choices, the lattice design and the main component descriptions.
DOI •	reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2019-TUPGW008
About •	paper received ※ 19 May 2019 paper accepted ※ 21 May 2019 issue date ※ 21 June 2019
Export •	reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

TUPRB083	Status of Clara Front End Commissioning and First User Experiments	1851
	D. Angal-Kalinin, A.D. Brynes, R.K. Buckley, S.R. Buckley, R.J. Cash, H.M. Castaneda Cortes, J.A. Clarke, P.A. Corlett, L.S. Cowie, K.D. Dumbell, D.J. Dunning, B.D. Fell, P. Goudket, A.R. Goulden, S.A. Griffiths, J. Henderson, F. Jackson, J.K. Jones, N.Y. Joshi, S.L. Mathisen, J.W. McKenzie, K.J. Middleman, B.L. Militsyn, A.J. Moss, B.D. Muratori, T.C.Q. Noakes, T.H. Pacey, M.D. Roper, Y.M. Saveliev, D.J. Scott, B.J.A. Shepherd, R.J. Smith, E.W. Snedden, M. Surman, N. Thompson, C. Tollervey, R. Valizadeh, D.A. Walsh, T.M. Weston, A.E. Wheelhouse, P.H. Williams STFC/DL/ASTeC, Daresbury, Warrington, Cheshire, United Kingdom A.D. Brynes, J.A. Clarke, K.D. Dumbell, D.J. Dunning, P. Goudket, F. Jackson, J.K. Jones, J.W. McKenzie, K.J. Middleman, B.L. Militsyn, A.J. Moss, B.D. Muratori, T.C.Q. Noakes, Y.M. Saveliev, D.J. Scott, B.J.A. Shepherd, M. Surman, N. Thompson, R. Valizadeh, A.E. Wheelhouse, P.H. Williams Cockcroft Institute, Warrington, Cheshire, United Kingdom R.F. Clarke, G. Cox, M.D. Hancock, J.P. Hindley, C. Hodgkinson, A. Oates, W. Smith, J.T.G. Wilson STFC/DL, Daresbury, Warrington, Cheshire, United Kingdom L.S. Cowie Cockcroft Institute, Lancaster University, Lancaster, United Kingdom N.Y. Joshi, T.H. Pacey UMAN, Manchester, United Kingdom
	CLARA (Compact Linear Accelerator for Research and Applications) is a test facility for Free Electron Laser (FEL) research and other applications at STFC’s Daresbury Laboratory. The first exploitation period using CLARA Front End (FE) provided a range of beam parameters to 12 user experiments. Beam line to Beam Area 1 (BA1) was commissioned and optimised for these experiments, some involving TW laser integration. In addition to the user exploitation programme, significant advances were made to progress on machine development. This paper summarises these developments and presents the near future plan for CLARA.
DOI •	reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2019-TUPRB083
About •	paper received ※ 14 May 2019 paper accepted ※ 22 May 2019 issue date ※ 21 June 2019
Export •	reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

THPMP038	Collaborative Strategies for Meeting the Global Need for Cancer Radiation Therapy Treatment Systems	3526
	M. Dosanjh, P. Collier, I. Syratchev, W. Wuensch CERN, Geneva, Switzerland A. Aggarwal KCL, London, United Kingdom D. Angal-Kalinin, P.A. McIntosh, B.L. Militsyn STFC/DL/ASTeC, Daresbury, Warrington, Cheshire, United Kingdom R. Apsimon Cockcroft Institute, Lancaster University, Lancaster, United Kingdom S.T. Boogert Royal Holloway, University of London, Surrey, United Kingdom G. Burt Lancaster University, Lancaster, United Kingdom N. Coleman, D.A. Pistenmaa ICEC, Washington, DC, USA A.W. Cross USTRAT/SUPA, Glasgow, United Kingdom I.V. Konoplev, S.L. Sheehy JAI, Oxford, United Kingdom
	The idea of designing affordable equipment and developing sustainable infrastructures for delivering radiation treatment for patients with cancer in countries that lack resources and expertise stimulated a first International Cancer Expert Corps (ICEC) championed, CERN-hosted workshop in Geneva in November 2016. Which has since been followed by three additional workshops involving the sponsorship and support from UK Science and Technology Facilities Council (STFC). One of the major challenges in meeting this need to deliver radiotherapy in low- and middle-income countries (LMIC) is to design a linear accelerator and associated instrumentation system which can be operated in locations where general infrastructures and qualified human resources are poor or lacking, power outages and water supply fluctuations can occur frequently and where climatic conditions might be harsh and challenging. In parallel it is essential to address education, training and mentoring requirements for current, as well as future novel radiation therapy treatment (RTT) systems.
DOI •	reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2019-THPMP038
About •	paper received ※ 11 May 2019 paper accepted ※ 22 May 2019 issue date ※ 21 June 2019
Export •	reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

Paper

Title

Page

THPMP041

A Comparative Study of Biological Effects of Electrons and Co-60 Gamma Rays on pBR322 Plasmid DNA

3533

SUSPFO119

use link to see paper's listing under its alternate paper code

K.L. Small, R.M. Jones
UMAN, Manchester, United Kingdom
D. Angal-Kalinin, M. Surman
Cockcroft Institute, Warrington, Cheshire, United Kingdom
A. Chadwick, N.T. Henthorn, K. Kirkby, M.J. Merchant, R. Morris, E. Santina
The Christie NHS Foundation Trust, Manchester, United Kingdom
R. Edge
Dalton Cumbrian Facility, University of Manchester, Cumbria, United Kingdom
R.J. Smith
STFC/DL/ASTeC, Daresbury, Warrington, Cheshire, United Kingdom

Very High-Energy Electron (VHEE) therapy is a rapidly developing field motivated by developments in high-gradient linacs. Advantages include sufficient penetration (>30 cm) for treatment of deep-seated tumours, measured insensitivity to inhomogeneities and rapid delivery time, making VHEE viable for treatment of heterogeneous regions, e.g. lung or bowel. Researchers at the University of Manchester and CERN have routinely produced accelerating gradients of ~100 MeV/m for the CLIC project. Suitable modification can result in a high gradient medical linac producing 250 MeV electrons within a treatment room. Radiobiological research for VHEE is vital to understand its use in radiotherapy and how it compares with conventional modalities. The goal of radiotherapy is to destroy tumour cells while sparing healthy cells, primarily by damaging DNA within the cancer cell. The study aim is to understand the fundamental interactions between VHEE and biological structures through plasmid irradiation studies - both computational, using the Monte Carlo GEANT4-DNA code, and experimental. Plasmid irradiation experiments have been carried out at using Co-60 gammas at the Dalton Cumbrian Facility and using 6-15 MeV electrons at the Christie NHS Foundation Trust to determine the type and quantity of damage caused to DNA by electron irradiation. These experiments are a world first in VHEE radiobiology, with further studies planned at higher energies using the CLARA and CLEAR facilities at Daresbury and CERN. These studies will also consider the effective dose range of VHEE with energy, as well as implications of damage on DNA. Research into this area of radiotherapy can provide a valuable addition to tools currently available to physicians in the fight against cancer.

DOI •

reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2019-THPMP041

About •

paper received ※ 15 May 2019 paper accepted ※ 22 May 2019 issue date ※ 21 June 2019

Export •

reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

TUPGW008

PERLE: A High Power Energy Recovery Facility

1396

W. Kaabi, I. Chaikovska, A. Stocchi, C. Vallerand
LAL, Orsay, France
D. Angal-Kalinin, J.W. McKenzie, B.L. Militsyn, P.H. Williams
STFC/DL/ASTeC, Daresbury, Warrington, Cheshire, United Kingdom
S.A. Bogacz, A. Hutton, F. Marhauser, R.A. Rimmer, C. Tennant
JLab, Newport News, Virginia, USA
S. Bousson, D. Longuevergne, G. Olivier, G. Olry
IPN, Orsay, France
O.S. Brüning, R. Calaga, L. Dassa, F. Gerigk, E. Jensen, P.A. Thonet
CERN, Geneva, Switzerland
B. Hounsell, M. Klein, C.P. Welsch
The University of Liverpool, Liverpool, United Kingdom
E.B. Levichev, Yu.A. Pupkov
BINP SB RAS, Novosibirsk, Russia

PERLE is a proposed high power Energy Recovery Linac, designed on multi-turn configuration, based on SRF technology, to be hosted at Orsay-France in a col-laborative effort between local laboratories: LAL and IPNO, together with an international collaboration involv-ing today: CERN, JLAB, STFC ASTeC Daresbury, Liverpool University and BINP Novosibirsk. PERLE will be a unique leading edge facility designed to push advances in accelerator technology, to provide intense and highly flexible test beams for component development. In its final configuration, PERLE provides a 500 MeV elec-tron beam using high current (20 mA) acceleration during three passes through 801.6 MHz cavities. This presenta-tion outlines the technological choices, the lattice design and the main component descriptions.

DOI •

reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2019-TUPGW008

About •

paper received ※ 19 May 2019 paper accepted ※ 21 May 2019 issue date ※ 21 June 2019

Export •

reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

TUPRB083

Status of Clara Front End Commissioning and First User Experiments

1851

D. Angal-Kalinin, A.D. Brynes, R.K. Buckley, S.R. Buckley, R.J. Cash, H.M. Castaneda Cortes, J.A. Clarke, P.A. Corlett, L.S. Cowie, K.D. Dumbell, D.J. Dunning, B.D. Fell, P. Goudket, A.R. Goulden, S.A. Griffiths, J. Henderson, F. Jackson, J.K. Jones, N.Y. Joshi, S.L. Mathisen, J.W. McKenzie, K.J. Middleman, B.L. Militsyn, A.J. Moss, B.D. Muratori, T.C.Q. Noakes, T.H. Pacey, M.D. Roper, Y.M. Saveliev, D.J. Scott, B.J.A. Shepherd, R.J. Smith, E.W. Snedden, M. Surman, N. Thompson, C. Tollervey, R. Valizadeh, D.A. Walsh, T.M. Weston, A.E. Wheelhouse, P.H. Williams
STFC/DL/ASTeC, Daresbury, Warrington, Cheshire, United Kingdom
A.D. Brynes, J.A. Clarke, K.D. Dumbell, D.J. Dunning, P. Goudket, F. Jackson, J.K. Jones, J.W. McKenzie, K.J. Middleman, B.L. Militsyn, A.J. Moss, B.D. Muratori, T.C.Q. Noakes, Y.M. Saveliev, D.J. Scott, B.J.A. Shepherd, M. Surman, N. Thompson, R. Valizadeh, A.E. Wheelhouse, P.H. Williams
Cockcroft Institute, Warrington, Cheshire, United Kingdom
R.F. Clarke, G. Cox, M.D. Hancock, J.P. Hindley, C. Hodgkinson, A. Oates, W. Smith, J.T.G. Wilson
STFC/DL, Daresbury, Warrington, Cheshire, United Kingdom
L.S. Cowie
Cockcroft Institute, Lancaster University, Lancaster, United Kingdom
N.Y. Joshi, T.H. Pacey
UMAN, Manchester, United Kingdom

CLARA (Compact Linear Accelerator for Research and Applications) is a test facility for Free Electron Laser (FEL) research and other applications at STFC’s Daresbury Laboratory. The first exploitation period using CLARA Front End (FE) provided a range of beam parameters to 12 user experiments. Beam line to Beam Area 1 (BA1) was commissioned and optimised for these experiments, some involving TW laser integration. In addition to the user exploitation programme, significant advances were made to progress on machine development. This paper summarises these developments and presents the near future plan for CLARA.

DOI •

reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2019-TUPRB083

About •

paper received ※ 14 May 2019 paper accepted ※ 22 May 2019 issue date ※ 21 June 2019

Export •

reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

THPMP038

Collaborative Strategies for Meeting the Global Need for Cancer Radiation Therapy Treatment Systems

3526

M. Dosanjh, P. Collier, I. Syratchev, W. Wuensch
CERN, Geneva, Switzerland
A. Aggarwal
KCL, London, United Kingdom
D. Angal-Kalinin, P.A. McIntosh, B.L. Militsyn
STFC/DL/ASTeC, Daresbury, Warrington, Cheshire, United Kingdom
R. Apsimon
Cockcroft Institute, Lancaster University, Lancaster, United Kingdom
S.T. Boogert
Royal Holloway, University of London, Surrey, United Kingdom
G. Burt
Lancaster University, Lancaster, United Kingdom
N. Coleman, D.A. Pistenmaa
ICEC, Washington, DC, USA
A.W. Cross
USTRAT/SUPA, Glasgow, United Kingdom
I.V. Konoplev, S.L. Sheehy
JAI, Oxford, United Kingdom

The idea of designing affordable equipment and developing sustainable infrastructures for delivering radiation treatment for patients with cancer in countries that lack resources and expertise stimulated a first International Cancer Expert Corps (ICEC) championed, CERN-hosted workshop in Geneva in November 2016. Which has since been followed by three additional workshops involving the sponsorship and support from UK Science and Technology Facilities Council (STFC). One of the major challenges in meeting this need to deliver radiotherapy in low- and middle-income countries (LMIC) is to design a linear accelerator and associated instrumentation system which can be operated in locations where general infrastructures and qualified human resources are poor or lacking, power outages and water supply fluctuations can occur frequently and where climatic conditions might be harsh and challenging. In parallel it is essential to address education, training and mentoring requirements for current, as well as future novel radiation therapy treatment (RTT) systems.

DOI •

reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2019-THPMP038

About •

paper received ※ 11 May 2019 paper accepted ※ 22 May 2019 issue date ※ 21 June 2019

Export •

reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)