The Joint Accelerator Conferences Website (JACoW) is an international collaboration that publishes the proceedings of accelerator conferences held around the world.
TY - CONF AU - Barlow, R.J. AU - Thongjerm, P. ED - Schaa, Volker RW ED - Arduini, Gianluigi ED - Pranke, Juliana ED - Seidel, Mike ED - Lindroos, Mats TI - Biological Effectiveness of Proton and Ion Beam Therapy: Studies Using G4-DNA J2 - Proc. of IPAC2017, Copenhagen, Denmark, 14â19 May, 2017 C1 - Copenhagen, Denmark T2 - International Particle Accelerator Conference T3 - 8 LA - english AB - We have used the Geant4-DNA program to investigate on a radiobiological level the interaction of various types of particles within cells, to identify relationships between irradiation and damage to DNA, leading to cell death. Although the physical attributes of particle therapy clearly hold a benefit over conventional radiotherapy, the biological effects hold uncertainties, and modelling the way particles interact with tissue on a cellular level can reduce these. The understanding of the energy deposition pattern along the particle track and consequent probabilities of producing DNA cluster breaks enables us to predict the effects of a particle beam on a microscopic level, which can aid treatment planning. PB - JACoW CP - Geneva, Switzerland SP - 4761 EP - 4764 KW - proton KW - ion KW - simulation KW - target KW - experiment DA - 2017/05 PY - 2017 SN - 978-3-95450-182-3 DO - 10.18429/JACoW-IPAC2017-THPVA131 UR - http://jacow.org/ipac2017/papers/thpva131.pdf ER -