The Joint Accelerator Conferences Website (JACoW) is an international collaboration that publishes the proceedings of accelerator conferences held around the world.
TY - CONF AU - Amin, A. AU - Barlow, R.J. AU - Hoehr, C.M. AU - Infantino, A. AU - Lindsay, C. ED - Schaa, Volker RW ED - Arduini, Gianluigi ED - Pranke, Juliana ED - Seidel, Mike ED - Lindroos, Mats TI - Modelling PET Radionuclides Production in Tissue and External Targets Using Geant4 J2 - Proc. of IPAC2017, Copenhagen, Denmark, 14â19 May, 2017 C1 - Copenhagen, Denmark T2 - International Particle Accelerator Conference T3 - 8 LA - english AB - The Proton Therapy Facility in TRIUMF provides 74 MeV protons extracted from a 500 MeV H⁻ cyclotron for ocular melanoma treatments. During treatment, positron emitting radionuclides such as C-11, O-15 and N-13 are produced in patient tissue. Using PET scanners, the isotopic activity distribution can be measured for in-vivo range verification. A second cyclotron, the TR13, provides 13 MeV protons onto liquid targets for the production of PET radionuclides such as F-18, N-13 or Ga-68, for medical applications. The aim of this work was to validate Geant4 against FLUKA and experimental measurements for production of the above-mentioned isotopes using the two cyclotrons. The results show variable degrees of agreement. For proton therapy, the proton-range agreement was within 2 mm for C-11 activity, whereas N-13 disagreed. For liquid targets at the TR13 the average absolute deviation ratio between FLUKA and experiment was 1.9±2.8, whereas the average absolute deviation ratio between Geant4 and experiment was 0.6±0.4. This is due to the uncertainties present in experimentally determined reaction cross sections. PB - JACoW CP - Geneva, Switzerland SP - 4757 EP - 4760 DA - 2017/05 PY - 2017 SN - 978-3-95450-182-3 DO - 10.18429/JACoW-IPAC2017-THPVA130 UR - http://jacow.org/ipac2017/papers/thpva130.pdf ER -