| Paper | Title | Page |
|---|---|---|
THBO03 |
Implementation of Accurate Dose Delivery Control at FLASH Dose Rates at PARTREC | |
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| The University Medical Center Groningen (UMCG) and the University of Groningen (UoG) have recently established the Particle Therapy Research Center (PARTREC) for accelerator based research on radiobiology and instrumentation for particle therapy. PARTREC uses the AGOR cyclotron to produce proton beam (up to 190 MeV) and heavy ion (helium/carbon) beams (up to 90 MeV/u). The facility builds upon previous expertise in accelerator physics, instrumentation and radiobiology of the KVI-CART institute. In recent years the use of high dose rate hypo fractionated treatment of cancer (FLASH) has become a topic of high interest to the radiobiology and particle therapy community because of its potential to reduce damage to normal tissues as compared to conventional treatment while not affecting the tumor control [1]. We report on the development of a flexible dose delivery system for FLASH research allowing proton irradiations at dose rates of 40 Gy/s to 100 Gy/s. The field is produced using scattering or (spot)scanning. The system allows to introduce beam time structure ranging from approx. 5-µs pulses with a frequency up to 1 kHz up to a CW dose delivery. This flexibility also allows us to generate TWIN FLASH BEAMS, which reproduce the spatial and time structure as used at clinical proton facilities that can affect the FLASH effect. A TWIN BEAM facilitates a fast translation of technical developments and pre-clinical radiobiology research to the clinic. The aim is to have the facility available for radiobiology experiments beginning of 2023. In parallel we are also working on beam/control and monitoring techniques to increase the dose rate in the direction of 1000 Gy/s. For this purpose we are investigating new beam monitoring techniques, for example the CWCT from Bergoz [2]. And we will work on connecting dosimetry at low dose rate with that at high dose rate. [1] E. Diffenderfer et al. DOI: 10.1002/mp.15276 [2] M. Xiao et al. https://ibic2022.vrws.de/papers/mop33.pdf | ||
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