TUAO02
PARTREC, Groningen, The Netherlands
THBO03
PARTREC, Groningen, The Netherlands
| Paper | Title | Page |
|---|---|---|
TUAO02 |
Establishment of the New Particle Therapy Research Center (PARTREC) at UMCG Groningen | |
|
||
| After 25 years of successful research in the nuclear and radiation physics domain, the KVI-CART research center in Groningen is upgraded and re-established as the PARticle Therapy REsearch Center (PARTREC). Using the superconducting cyclotron AGOR and being embedded within the University Medical Center Groningen, it operates in close collaboration with the Groningen Proton Therapy Center. PARTREC uniquely combines radiation physics, medical physics, biology and radiotherapy research with an R&D program to improve hadron therapy technology and advanced radiation therapy for cancer. A number of further upgrades, scheduled for completion in 2023, will establish a wide range of irradiation modalities, such as pencil beam scanning, shoot-through with high energy protons and SOBP for protons, helium and carbon ions. Delivery of spatial fractionation (GRID) and dose rates over 300 Gy/s (FLASH) are envisioned. In addition, PARTREC delivers a variety of ion beams and infrastructure for radiation hardness experiments conducted by scientific and commercial communities, and nuclear science research in collaboration with the Faculty of Science and Engineering of the University of Groningen. | ||
|
|
Slides TUAO02 [2.479 MB] | |
| Cite • | reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml) | |
THBO03 |
Implementation of Accurate Dose Delivery Control at FLASH Dose Rates at PARTREC | |
|
||
| The University Medical Center Groningen (UMCG) and the University of Groningen (UoG) have recently established the Particle Therapy Research Center (PARTREC) for accelerator based research on radiobiology and instrumentation for particle therapy. PARTREC uses the AGOR cyclotron to produce proton beam (up to 190 MeV) and heavy ion (helium/carbon) beams (up to 90 MeV/u). The facility builds upon previous expertise in accelerator physics, instrumentation and radiobiology of the KVI-CART institute. In recent years the use of high dose rate hypo fractionated treatment of cancer (FLASH) has become a topic of high interest to the radiobiology and particle therapy community because of its potential to reduce damage to normal tissues as compared to conventional treatment while not affecting the tumor control [1]. We report on the development of a flexible dose delivery system for FLASH research allowing proton irradiations at dose rates of 40 Gy/s to 100 Gy/s. The field is produced using scattering or (spot)scanning. The system allows to introduce beam time structure ranging from approx. 5-µs pulses with a frequency up to 1 kHz up to a CW dose delivery. This flexibility also allows us to generate TWIN FLASH BEAMS, which reproduce the spatial and time structure as used at clinical proton facilities that can affect the FLASH effect. A TWIN BEAM facilitates a fast translation of technical developments and pre-clinical radiobiology research to the clinic. The aim is to have the facility available for radiobiology experiments beginning of 2023. In parallel we are also working on beam/control and monitoring techniques to increase the dose rate in the direction of 1000 Gy/s. For this purpose we are investigating new beam monitoring techniques, for example the CWCT from Bergoz [2]. And we will work on connecting dosimetry at low dose rate with that at high dose rate. [1] E. Diffenderfer et al. DOI: 10.1002/mp.15276 [2] M. Xiao et al. https://ibic2022.vrws.de/papers/mop33.pdf | ||
| Cite • | reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml) | |