JACoW is a publisher in Geneva, Switzerland that publishes the proceedings of accelerator conferences held around the world by an international collaboration of editors.
TY - CONF AU - Wang, Q.J. AU - Gong, Y.H. AU - Liu, J.C. AU - Liu, Q. AU - Sui, L. AU - Wang, Y. ED - Zhang, Tianjue ED - Schaa, Volker R.W. ED - An, Shizhong ED - Kiselev, Daniela ED - Liu, Yuntao ED - Li, Pengzhan TI - Effect of 90 MeV Proton Irradiation on Spleen Injury in C57BL/6J Mice J2 - Proc. of CYCLOTRONS2022, Beijing, China, 05-09 December 2022 CY - Beijing, China T2 - International Conference on Cyclotrons and their Applications T3 - 23 LA - english AB - Proton therapy has become one of the most important physiotherapies for tumors in the world, which can greatly improve the cure rate of tumors that are ineffective by conventional treatments. In addition, proton is also the main source of radiation in space environment. Therefore, it is of great scientific significance to use accelerators to carry out basic research on proton radiotherapy and space radiobiology, which can provide technical support and basic data for the optimal design of proton therapy and risk assessment of personnel in space environment. In this study, C57 mice were irradiated with 0, 0.2, 0.5 and 2 Gy by 90 MeV protons from 100 MeV cyclotron of China Institute of Atomic Energy. The mice were killed one day after irradiation. Body weight change and spleen organ coefficient were calculated. The expression of DNA damage-related protein γ H2AX was detected by western blotting. The results showed that compared with the control group, the body weight of mice in each irradiation group had no significant change, and the spleen organ coefficient decreased, indicating that the spleen atrophied after proton radiation, especially in 2 Gy. The results of Western blotting showed that the expression of γ H2AX in spleen increased significantly on the 1 day after irradiation, especially in 0.5 and 2 Gy, indicating that the spleen DNA damage was the serious on the 1 day after proton radiation. PB - JACoW Publishing CP - Geneva, Switzerland SP - 324 EP - 326 KW - radiation KW - proton KW - experiment KW - controls KW - cyclotron DA - 2023/10 PY - 2023 SN - 2673-5482 SN - 978-3-95450-212-7 DO - doi:10.18429/JACoW-CYCLOTRONS2022-THPO011 UR - https://jacow.org/cyclotrons2022/papers/thpo011.pdf ER -