IPAC2014 - List of Authors (Green, S.)

Paper	Title	Page
WEPRO099	A Study of the Production of Neutrons for Boron Neutron Capture Therapy using a Proton Accelerator	2195
	T.R. Edgecock University of Huddersfield, Huddersfield, United Kingdom J.R.J. Bennett STFC/RAL/ISIS, Chilton, Didcot, Oxon, United Kingdom S. Green University Birmingham, Birmingham, United Kingdom B. Phoenix, M.C. Scott Birmingham University, Birmingham, United Kingdom
	Boron Neutron Capture Therapy (BNCT) is a binary cancer therapy particularly well-suited to treating aggressive tumours that exhibit a high degree of infiltration of the surrounding healthy tissue. Such tumours, for example of the brain and lung, provide some of the most challenging problems in oncology. The first element of the therapy is boron-10 which is preferentially introduced into the cancerous cells using a carrier compound. Boron-10 has a very high capture cross-section with the other element of the therapy, thermal neutrons, resulting in the production of a lithium nucleus and an alpha particle which destroy the cell they are created in. However, a large flux of neutrons is required and until recently the only source used was a nuclear reactor. In Birmingham, studies of an existing BNCT facility using a 2.8 MeV proton beam and a solid lithium target have found a way to increase the beam power to a sufficient level to allow clinical trials, while maintaining the target solid. In this paper, we will introduce BNCT, describe the work in Birmingham and compare with other accelerator-driven BNCT projects around the World.
DOI •	reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2014-WEPRO099
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Paper

Title

Page

A Study of the Production of Neutrons for Boron Neutron Capture Therapy using a Proton Accelerator

2195

T.R. Edgecock
University of Huddersfield, Huddersfield, United Kingdom
J.R.J. Bennett
STFC/RAL/ISIS, Chilton, Didcot, Oxon, United Kingdom
S. Green
University Birmingham, Birmingham, United Kingdom
B. Phoenix, M.C. Scott
Birmingham University, Birmingham, United Kingdom

Boron Neutron Capture Therapy (BNCT) is a binary cancer therapy particularly well-suited to treating aggressive tumours that exhibit a high degree of infiltration of the surrounding healthy tissue. Such tumours, for example of the brain and lung, provide some of the most challenging problems in oncology. The first element of the therapy is boron-10 which is preferentially introduced into the cancerous cells using a carrier compound. Boron-10 has a very high capture cross-section with the other element of the therapy, thermal neutrons, resulting in the production of a lithium nucleus and an alpha particle which destroy the cell they are created in. However, a large flux of neutrons is required and until recently the only source used was a nuclear reactor. In Birmingham, studies of an existing BNCT facility using a 2.8 MeV proton beam and a solid lithium target have found a way to increase the beam power to a sufficient level to allow clinical trials, while maintaining the target solid. In this paper, we will introduce BNCT, describe the work in Birmingham and compare with other accelerator-driven BNCT projects around the World.

DOI •

reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2014-WEPRO099

Export •

reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)