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The cyclotron CIME is presently used at GANIL for the acceleration of SPIRAL1 radioactive beams. One of the goals of the SPIRAL2 project is to produce, post-accelerate and use in the existing experimental areas much higher intensity secondary beams induced by uranium fission like neutron-rich krypton, xenon, tin isotopes, and many others. Intensity may reach 1010 pps. Specific developments are needed for secondary beam diagnostics. Improvement of mass separation is also necessary, and the Vertical Mass Separator (VMS) is specially developed for this purpose. However, the main concern is related to the high radioactivity linked to RIB high intensity. Safety and radioprotection issues will require modifications of the installation with special care for the maintenance of the cyclotron. The experience of the SPIRAL1 beams, in terms of beam losses and equipment contamination, is especially useful to define the necessary modifications.
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