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| THPVA131 |
Biological Effectiveness of Proton and Ion Beam Therapy: Studies Using G4-DNA |
4761 |
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- R.J. Barlow
University of Huddersfield, Huddersfield, United Kingdom
- P. Thongjerm
IIAA, Huddersfield, United Kingdom
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We have used the Geant4-DNA program to investigate on a radiobiological level the interaction of various types of particles within cells, to identify relationships between irradiation and damage to DNA, leading to cell death. Although the physical attributes of particle therapy clearly hold a benefit over conventional radiotherapy, the biological effects hold uncertainties, and modelling the way particles interact with tissue on a cellular level can reduce these. The understanding of the energy deposition pattern along the particle track and consequent probabilities of producing DNA cluster breaks enables us to predict the effects of a particle beam on a microscopic level, which can aid treatment planning.
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| DOI • |
reference for this paper
※ https://doi.org/10.18429/JACoW-IPAC2017-THPVA131
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