NAPAC2019 - Table of Session: TUXBA (Tuesday Parallel Session 1)

Paper	Title	Page
TUXBA1	Department of Energy Isotope Program Accelerator Production of Isotopes
	M.A. Garland DOE/NP, Germantown, USA
	The United States Department of Energy’s Isotope Program (DOE IP) produces radioactive and enriched stable isotopes that are in short supply to meet the nation’s needs for research and for commercial and national security applications. DOE has more than twenty-one laboratories, many with nuclear reactors, particle accelerators, and processing facilities useful for the production of isotopes. This talk will focus on the DOE IP’s accelerator production facilities, presenting descriptions of the facilities, the isotopes they produce and their applications. An overview of the science of accelerator production methods will be also be provided. Isotope production is accomplished using proton accelerators at the Brookhaven and Los Alamos National Laboratories, electron accelerators at the Argonne National Laboratory and Thomas Jefferson National Accelerator Facility, and a multi-particle cyclotron at the University of Washington. The Facility for Rare Isotope Beams, under construction at Michigan State University, will harvest large quantities of many rare isotopes to support scientific research and applications.
	Slides TUXBA1 [13.602 MB]
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TUXBA2	Novel Medical Linacs for Challenging Environments
	D. Pistenmaa ICEC, Washington, DC, USA M. Dosanjh CERN, Meyrin, Switzerland
	25 millions cancer cases are predicted in 2035, 65-70% will occur in low and middle income countries (LMICs). The current generation of linear accelerators in use in upper-income countries often do not function well in the adverse conditions in LMICs as regular interruptions to energy supply, lack of air temperature control in buildings and weak health systems between others. A new generation of environmental friendly radiotherapy accelerator that consumes little power on standby and has reduction heat production, low instantaneous power demand and local power storage would reduce reliance on the electricity grid and is in development. The talk will describe the effort made in this sense.
	Slides TUXBA2 [38.498 MB]
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TUXBA3	Robust Thermoacoustic Range Verification for Pulsed Ion Beam Therapy	294
	S.K. Patch UWM, Milwaukee, Wisconsin, USA B.M. Brahim, D. Santiago-Gonzalez ANL, Lemont, Illinois, USA
	Funding: * Supported by the U.S D.O.E., Office of Nuclear Physics, under Contract No. DE-AC02-06CH11357. Measurements were performed at ANL’s ATLAS facility, which is a DOE Office of Science User Facility. Lack of online range verification generally limits application of proton therapy to cancers in the brain, spine, and to pediatric patients. Previously, thermoacoustic range verification (TARV) has been demonstrated in weakly scattering media with known sound speed [1]. At ATLAS, we demonstrated the accuracy and robustness of TARV relative to ultrasound (US) images despite acoustic heterogeneity and sound speed errors representing in vivo conditions [2]. 250 ns pulses deposited 0.26 Gy of 16 MeV protons and 2.3 Gy of 60 MeV helium ions into liquid targets. TA signals were detected by an US array that also generated US images. An air gap phantom displaced the Bragg peak by 6.5 mm and the scanner’s propagation speed setting was altered by ±5%. Weak and strong scatterers were placed between the Bragg peak and US array. Estimated Bragg peak locations were translated 6.5 mm by the air gap phantom and agreed with TRIM simulations to within 0.3 mm, even when TA emissions traveled through a strong acoustic scatterer. Soundspeed errors dilated, and acoustic heterogeneities deformed both US images and TA range estimates, confirming that TARV is accurate relative to US images. [1] Hickling, et al, Med Phys, 45(7), 2018. (review article) [2] S. Patch, D. Santiago, & B. Mustapha, Med Phys, 46(1), 2019.
	Slides TUXBA3 [4.449 MB]
DOI •	reference for this paper ※ https://doi.org/10.18429/JACoW-NAPAC2019-TUXBA3
About •	paper received ※ 27 August 2019 paper accepted ※ 31 August 2019 issue date ※ 08 October 2019
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TUXBA4	Rapid Radio-Frequency Beam Energy Modulator for Proton Therapy	298
WEPLM24	use link to see paper's listing under its alternate paper code
	X. Lu, G.B. Bowden, V.A. Dolgashev, Z. Li, E.A. Nannipresenter, A.V. Sy, S.G. Tantawi SLAC, Menlo Park, California, USA
	Funding: This work is supported by US Department of Energy (DOE) Contract No. DE-AC02-76SF00515. We present the design for a rapid proton energy modulator with radio-frequency (RF) accelerator cavities. The energy modulator is designed as a multi-cell one-meter long accelerator working at 2.856 GHz. We envision that each individual accelerator cavity is powered by a 400 kW low-voltage klystron to provide an accelerating / decelerating gradient of 30 MV/m. We have performed beam dynamics simulations showing that the modulator can provide ± 30MeV of beam energy change, with an energy spread of 3 MeV for a 7 mm long (full length) proton bunch. A prototype experiment of a single cell is in preparation at the Next Linear Collider Test Accelerator (NLCTA) at SLAC.
	Slides TUXBA4 [3.275 MB]
DOI •	reference for this paper ※ https://doi.org/10.18429/JACoW-NAPAC2019-TUXBA4
About •	paper received ※ 27 August 2019 paper accepted ※ 06 September 2019 issue date ※ 08 October 2019
Export •	reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

Paper

Title

Page

TUXBA1

Department of Energy Isotope Program Accelerator Production of Isotopes

M.A. Garland
DOE/NP, Germantown, USA

The United States Department of Energy’s Isotope Program (DOE IP) produces radioactive and enriched stable isotopes that are in short supply to meet the nation’s needs for research and for commercial and national security applications. DOE has more than twenty-one laboratories, many with nuclear reactors, particle accelerators, and processing facilities useful for the production of isotopes. This talk will focus on the DOE IP’s accelerator production facilities, presenting descriptions of the facilities, the isotopes they produce and their applications. An overview of the science of accelerator production methods will be also be provided. Isotope production is accomplished using proton accelerators at the Brookhaven and Los Alamos National Laboratories, electron accelerators at the Argonne National Laboratory and Thomas Jefferson National Accelerator Facility, and a multi-particle cyclotron at the University of Washington. The Facility for Rare Isotope Beams, under construction at Michigan State University, will harvest large quantities of many rare isotopes to support scientific research and applications.

Slides TUXBA1 [13.602 MB]

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TUXBA2

Novel Medical Linacs for Challenging Environments

D. Pistenmaa
ICEC, Washington, DC, USA
M. Dosanjh
CERN, Meyrin, Switzerland

25 millions cancer cases are predicted in 2035, 65-70% will occur in low and middle income countries (LMICs). The current generation of linear accelerators in use in upper-income countries often do not function well in the adverse conditions in LMICs as regular interruptions to energy supply, lack of air temperature control in buildings and weak health systems between others. A new generation of environmental friendly radiotherapy accelerator that consumes little power on standby and has reduction heat production, low instantaneous power demand and local power storage would reduce reliance on the electricity grid and is in development. The talk will describe the effort made in this sense.

Slides TUXBA2 [38.498 MB]

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TUXBA3

Robust Thermoacoustic Range Verification for Pulsed Ion Beam Therapy

294

S.K. Patch
UWM, Milwaukee, Wisconsin, USA
B.M. Brahim, D. Santiago-Gonzalez
ANL, Lemont, Illinois, USA

Funding: * Supported by the U.S D.O.E., Office of Nuclear Physics, under Contract No. DE-AC02-06CH11357. Measurements were performed at ANL’s ATLAS facility, which is a DOE Office of Science User Facility.
Lack of online range verification generally limits application of proton therapy to cancers in the brain, spine, and to pediatric patients. Previously, thermoacoustic range verification (TARV) has been demonstrated in weakly scattering media with known sound speed [1]. At ATLAS, we demonstrated the accuracy and robustness of TARV relative to ultrasound (US) images despite acoustic heterogeneity and sound speed errors representing in vivo conditions [2]. 250 ns pulses deposited 0.26 Gy of 16 MeV protons and 2.3 Gy of 60 MeV helium ions into liquid targets. TA signals were detected by an US array that also generated US images. An air gap phantom displaced the Bragg peak by 6.5 mm and the scanner’s propagation speed setting was altered by ±5%. Weak and strong scatterers were placed between the Bragg peak and US array. Estimated Bragg peak locations were translated 6.5 mm by the air gap phantom and agreed with TRIM simulations to within 0.3 mm, even when TA emissions traveled through a strong acoustic scatterer. Soundspeed errors dilated, and acoustic heterogeneities deformed both US images and TA range estimates, confirming that TARV is accurate relative to US images.
[1] Hickling, et al, Med Phys, 45(7), 2018. (review article)
[2] S. Patch, D. Santiago, & B. Mustapha, Med Phys, 46(1), 2019.

Slides TUXBA3 [4.449 MB]

DOI •

reference for this paper ※ https://doi.org/10.18429/JACoW-NAPAC2019-TUXBA3

About •

paper received ※ 27 August 2019 paper accepted ※ 31 August 2019 issue date ※ 08 October 2019

Export •

reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

TUXBA4

Rapid Radio-Frequency Beam Energy Modulator for Proton Therapy

298

WEPLM24

use link to see paper's listing under its alternate paper code

X. Lu, G.B. Bowden, V.A. Dolgashev, Z. Li, E.A. Nannipresenter, A.V. Sy, S.G. Tantawi
SLAC, Menlo Park, California, USA

Funding: This work is supported by US Department of Energy (DOE) Contract No. DE-AC02-76SF00515.
We present the design for a rapid proton energy modulator with radio-frequency (RF) accelerator cavities. The energy modulator is designed as a multi-cell one-meter long accelerator working at 2.856 GHz. We envision that each individual accelerator cavity is powered by a 400 kW low-voltage klystron to provide an accelerating / decelerating gradient of 30 MV/m. We have performed beam dynamics simulations showing that the modulator can provide ± 30MeV of beam energy change, with an energy spread of 3 MeV for a 7 mm long (full length) proton bunch. A prototype experiment of a single cell is in preparation at the Next Linear Collider Test Accelerator (NLCTA) at SLAC.

Slides TUXBA4 [3.275 MB]

DOI •

reference for this paper ※ https://doi.org/10.18429/JACoW-NAPAC2019-TUXBA4

About •

paper received ※ 27 August 2019 paper accepted ※ 06 September 2019 issue date ※ 08 October 2019

Export •

reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)