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TY - CONF AU - van der Kraaij, E. AU - Bertora, L. AU - Carrozzi, A. AU - Gantz, S. AU - Hoffmann, A. AU - Karsch, L. AU - Lühr, A. AU - Oborn, B. AU - Pawelke, J. AU - Schellhammer, S. AU - Serra, A. AU - Smeets, J. ED - Conradie, Lowry ED - De Villiers, John Garrett ED - Schaa, Volker RW TI - MRI-Guided-PT: Integrating an MRI in a Proton Therapy System J2 - Proc. of Cyclotrons2019, Cape Town, South Africa, 23-27 September 2019 CY - Cape Town, South Africa T2 - International Conference on Cyclotrons and their Applications T3 - 22 LA - english AB - Integration of magnetic resonance imaging (MRI) in proton therapy (PT) has the potential to improve tumor-targeting precision. However, it is technically challenging to integrate an MRI scanner at the beam isocenter of a PT system due to space constraints and electromagnetic interactions between the two systems. We assessed the technical risks and challenges, and present a concept for the mechanical integration of a 0.5T MRI scanner (ASG MR-Open) into a PT gantry (IBA ProteusONE). Finite element simulations assess the perturbation of the gantry’s elements on the homogeneity of the scanner’s static magnetic field. MC simulations estimate the effect of the scanner’s magnetic field on the proton dose deposition. To test the technical feasibility, a first experimental setup was realized at the PT center in Dresden, combining a 0.22T open MRI scanner with a static proton beam line. Results show that the image quality is not degraded by proton beam irradiation if the acquisition is synchronized with beam line operation. The beam energy dependent proton beam deflection due to the scanner’s magnetic field is significant and needs to be corrected for in treatment planning and dose delivery. PB - JACoW Publishing CP - Geneva, Switzerland SP - 144 EP - 147 KW - proton KW - HOM KW - GUI KW - FEM KW - simulation DA - 2020/06 PY - 2020 SN - 978-3-95450-205-9 DO - doi:10.18429/JACoW-Cyclotrons2019-TUB03 UR - http://jacow.org/cyclotrons2019/papers/tub03.pdf ER -